Curcumin loaded zinc oxide nanoparticles for activity-enhanced antibacterial and anticancer applications.

Autor:	Perera WPTD; Academy of the Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.; Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka., Dissanayake RK; Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.; Department of Pharmacy and Pharmaceutical Sciences, Faculty of Allied Health Sciences, University of Sri Jayewardenepura Gangodawila Nugegoda 10250 Sri Lanka rangad@sjp.ac.lk., Ranatunga UI; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Colombo 25 Kynsey Road Colombo 00800 Sri Lanka., Hettiarachchi NM; Academy of the Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.; Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka., Perera KDC; Academy of the Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.; Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka., Unagolla JM; Biomedical Engineering Program, Department of Bioengineering, College of Engineering, University of Toledo Toledo OH 43607 USA., De Silva RT; Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka., Pahalagedara LR; Sri Lanka Institute of Nanotechnology, Nanotechnology and Science Park Mahenwatte, Pitipana Homagama 10206 Sri Lanka.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2020 Aug 19; Vol. 10 (51), pp. 30785-30795. Date of Electronic Publication: 2020 Aug 19 (Print Publication: 2020).
DOI:	10.1039/d0ra05755j
Abstrakt:	Zinc oxide nanoparticles and curcumin have been shown to be excellent antimicrobial agents and promising anticancer agents, both on their own as well as in combination. Together, they have potential as alternatives/supplements to antibiotics and traditional anticancer drugs. In this study, different morphologies of zinc oxide-grafted curcumin nanocomposites (ZNP-Cs) were synthesized and characterized using SEM, TGA, FTIR, XRD and UV-vis spectrophotometry. Antimicrobial assays were conducted against both Gram negative and Gram-positive bacterial stains. Spherical ZnO-curcumin nanoparticles (SZNP-Cs) and rod-shaped ZnO-curcumin nanoparticles showed the most promising activity against tested bacterial strains. The inhibition zones for these curcumin-loaded ZnO nanocomposites were consistently larger than their bare counterparts or pure curcumin, revealing an additve effect between the ZnO and curcumin components. The potential anticancer activity of the synthesized nanocomposites was studied on the rhabdomyosarcoma RD cell line via MTT assay, while their cytotoxic effects were tested against human embryonic kidney cells using the resazurin assay. SZNP-Cs exhibited the best balance between the two, showing the lowest toxicity against healthy cells and good anticancer activity. The results of this investigation demonstrate that the nanomatrix synthesized can act as an effective, additively-enhanced combination delivery/therapeutic agent, holding promise for anticancer therapy and other biomedical applications. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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