Computational modeling of corneal and scleral collagen photocrosslinking.

Autor: Gerberich BG; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia., Wood-Yang AJ; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia., Radmand A; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia., Nichols LM; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia., Hejri A; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia., Schrader Echeverri E; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia., Gersch HG; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia., Prausnitz MR; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia; School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia. Electronic address: prausnitz@gatech.edu.
Jazyk: angličtina
Zdroj: Journal of controlled release : official journal of the Controlled Release Society [J Control Release] 2022 Jul; Vol. 347, pp. 314-329. Date of Electronic Publication: 2022 May 13.
DOI: 10.1016/j.jconrel.2022.04.042
Abstrakt: Scleral photocrosslinking is increasingly investigated for treatment of myopia and glaucoma. In this study a computational model was developed to predict crosslinking efficiency of visible/near infrared photosensitizers in the sclera. Photocrosslinking was validated against riboflavin corneal crosslinking experimental studies and subsequently modeled for the sensitizer, methylene blue, administered by retrobulbar injection to the posterior sclera and irradiated with a transpupillary light beam. Optimal ranges were determined for treatment parameters including light intensity, methylene blue concentration, injection volume, and inspired oxygen concentration. Additionally, sensitivity of crosslinking to various parameters was quantified. The most sensitive parameters were oxygen concentration in the injection solution, scleral thickness, and injection reservoir thickness (i.e., injection volume).
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Databáze: MEDLINE
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