Cephalotaxine homologous alkaloids from seeds of Cephalotaxus oliveri Mast.

Autor: Yu GX; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing, 100039, People's Republic of China., Yu Y; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China., Jing-Wu; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China., Zeng LH; Zhejiang University City College, Hangzhou, 310015, China. Electronic address: zenglh@zucc.edu.cn., Schinnerl J; Department of Botany and Biodiversity Research, University of Vienna, Rennweg 14, A-1030, Vienna, Austria., Cai XH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China. Electronic address: xhcai@mail.kib.ac.cn.
Jazyk: angličtina
Zdroj: Phytochemistry [Phytochemistry] 2022 Aug; Vol. 200, pp. 113220. Date of Electronic Publication: 2022 May 02.
DOI: 10.1016/j.phytochem.2022.113220
Abstrakt: Six undescribed isoquinoline alkaloids, named as cephaloliverines A-F, were isolated from the seeds of Cephalotaxus oliveri. They were identified by NMR and MS spectroscopic data analyses, combined with the time-dependent density functional theory ECD calculation for cephaloliverines A and B and also by X-ray crystal diffraction for cephaloliverine E. Biosynthetic considerations suggest that cephaloliverines A-D are homologous of cephalotaxine-, homoerythrina- and Erythrina-type alkaloids. The performed bioassay revealed no cytotoxic activity against cancer cells and no neuroprotective properties on HEI-OC-1 cells model.
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Databáze: MEDLINE
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