Bis Hexanoyl (R)-1,3-Butanediol, a Novel Ketogenic Ester, Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults.

Autor:	Crabtree CD; Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA., Blade T; Buck Institute for Research on Aging, Novato, California, USA., Hyde PN; Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA.; Department of Kinesiology, University of North Georgia, Dahlonega, Georgia, USA., Buga A; Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA., Kackley ML; Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA., Sapper TN; Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA., Panda O; Buck Institute for Research on Aging, Novato, California, USA., Roa-Diaz S; Buck Institute for Research on Aging, Novato, California, USA., Anthony JC; Juvenescence Ltd, Princeton, NJ, USA.; Nlumn LLC, Princeton, NJ, USA., Newman JC; Buck Institute for Research on Aging, Novato, California, USA.; Division of Geriatrics, UCSF, San Francisco, California, USA., Volek JS; Department of Human Sciences, The Ohio State University, Columbus, Ohio, USA., Stubbs BJ; Buck Institute for Research on Aging, Novato, California, USA.
Jazyk:	angličtina
Zdroj:	Journal of the American Nutrition Association [J Am Nutr Assoc] 2023 Feb; Vol. 42 (2), pp. 169-177. Date of Electronic Publication: 2022 Mar 25.
DOI:	10.1080/07315724.2021.2015476
Abstrakt:	Background: Ketosis has been reported to benefit healthspan and resilience, which has driven considerable interest in development of exogenous ketones to induce ketosis without dietary changes. Bis hexanoyl (R)-1,3-butanediol (BH-BD) is a novel ketone di-ester that can be used as a food ingredient that increases hepatic ketogenesis and blood beta-hydroxybutyrate (BHB) concentrations. Methods: Here, we provide the first description of blood ketone and metabolite kinetics for up to five hours after consumption of a beverage containing BH-BD by healthy adults ( n  = 8) at rest in three randomized, cross-over conditions (25 g + Meal (FEDH); 12.5 g + Meal (FEDL) ; 25 g + Fasted (FASTH)). Results: Consumption of BH-BD effectively raised plasma r-BHB concentrations to 0.8-1.7 mM in all conditions, and both peak r-BHB concentration and r-BHB area under the curve were greater with 25 g versus 12.5 g of BH-BD. Urinary excretion of r-BHB was <1 g. Plasma concentration of the non-physiological isoform s-BHB was increased to 20-60 µM in all conditions. BH-BD consumption decreased plasma glucose and free fatty acid concentrations; insulin was increased when BH-BD was consumed with a meal. Conclusions: These results demonstrate that consumption of BH-BD effectively induces exogenous ketosis in healthy adults at rest.
Databáze:	MEDLINE
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