Prodromal depression and subsequent risk of developing Parkinson's disease: a systematic review with meta-analysis.

Autor:	Bareeqa SB; Medical Graduate, Jinnah Medical & Dental College, Karachi, Sindh, 74800, Pakistan., Samar SS; Medical Student, Jinnah Sindh Medical University, Karachi, Sindh, 75510, Pakistan., Kamal S; Medical Student, Jinnah Sindh Medical University, Karachi, Sindh, 75510, Pakistan., Masood Y; Washington University in Saint Louis, MO 63130, USA., Allahyar; Bolan Medical Complex Hospital, Quetta, Balochistan, 87300, Pakistan., Ahmed SI; Department of Neurology, Neurology Resident, Saint Louis University, MO 63103, USA., Hayat G; Department of Neurology, Professor of Neurology, Saint Louis University, MO 63103, USA.
Jazyk:	angličtina
Zdroj:	Neurodegenerative disease management [Neurodegener Dis Manag] 2022 Jun; Vol. 12 (3), pp. 155-164. Date of Electronic Publication: 2022 May 05.
DOI:	10.2217/nmt-2022-0001
Abstrakt:	Aim: Parkinson's disease (PD) is a progressive neurological disorder that predominately affects dopaminergic neurons. We believe that this pooling of data will help to better understand the prodromal nature of depression in PD. Materials & methods: We conducted this study in accordance with PRISMA guidelines 2020. Fifteen eligible articles were shortlisted for final analysis. Risk of bias assessment was also conducted Results: The random-effect model revealed that the risk of subsequent PD in patients with prodromal depression was twice as likely (odds ratio, 2.04; 95% CI, 1.02-4.08) as compared with a healthy population. Conclusion: Our meta-analysis concluded that the subsequent risk of PD is significantly higher in patients with depression as compared with healthy individuals.
Databáze:	MEDLINE
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