Temporal irreversibility of neural dynamics as a signature of consciousness.

Autor:	de la Fuente LA; Department of Physics, University of Buenos Aires 1428, Argentina.; Institute of Cognitive and Translational Neuroscience, INECO Foundation, Favaloro University, Buenos Aires 1058, Argentina.; National Scientific and Technical Research Council, Buenos Aires 1425, Argentina., Zamberlan F; Department of Physics, University of Buenos Aires 1428, Argentina.; National Scientific and Technical Research Council, Buenos Aires 1425, Argentina.; Cognitive Science and Artificial Intelligence Department, Tilburg University, Tilburg 5000, The Netherlands., Bocaccio H; Department of Physics, University of Buenos Aires 1428, Argentina.; National Scientific and Technical Research Council, Buenos Aires 1425, Argentina., Kringelbach M; Centre for Eudaimonia and Human Flourishing, Linacre College, University of Oxford OX1, UK.; Department of Psychiatry, University of Oxford, Oxford OX3, UK.; Center for Music in the Brain, Department of Clinical Medicine, Aarhus University 8000, DK., Deco G; Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona 08018, Spain.; Institució Catalana de la Recerca i Estudis Avançats (ICREA), Barcelona 08010, Spain.; Department of Neuropsychology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig 04103, Germany.; School of Psychological Sciences, Monash University, Melbourne, Clayton VIC 3800, Australia., Perl YS; Department of Physics, University of Buenos Aires 1428, Argentina.; Center for Brain and Cognition, Computational Neuroscience Group, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona 08018, Spain., Pallavicini C; Department of Physics, University of Buenos Aires 1428, Argentina.; National Scientific and Technical Research Council, Buenos Aires 1425, Argentina., Tagliazucchi E; Department of Physics, University of Buenos Aires 1428, Argentina.; National Scientific and Technical Research Council, Buenos Aires 1425, Argentina.; Latin American Brain Health Institute (BrainLat), Universidad Adolfo Ibanez, Santiago 7910000, Chile.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2023 Feb 20; Vol. 33 (5), pp. 1856-1865.
DOI:	10.1093/cercor/bhac177
Abstrakt:	Dissipative systems evolve in the preferred temporal direction indicated by the thermodynamic arrow of time. The fundamental nature of this temporal asymmetry led us to hypothesize its presence in the neural activity evoked by conscious perception of the physical world, and thus its covariance with the level of conscious awareness. We implemented a data-driven deep learning framework to decode the temporal inversion of electrocorticography signals acquired from non-human primates. Brain activity time series recorded during conscious wakefulness could be distinguished from their inverted counterparts with high accuracy, both using frequency and phase information. However, classification accuracy was reduced for data acquired during deep sleep and under ketamine-induced anesthesia; moreover, the predictions obtained from multiple independent neural networks were less consistent for sleep and anesthesia than for conscious wakefulness. Finally, the analysis of feature importance scores highlighted transitions between slow ($\approx$20 Hz) and fast frequencies (>40 Hz) as the main contributors to the temporal asymmetry observed during conscious wakefulness. Our results show that a preferred temporal direction is manifest in the neural activity evoked by conscious mentation and in the phenomenology of the passage of time, establishing common ground to tackle the relationship between brain and subjective experience. (© The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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