| Autor: |
Osborne KJ; Department of Psychology, Northwestern University, Evanston Campus., Zhang W; Department of Psychology, San Diego State University., Farrens J; Department of Psychology, San Diego State University., Geiger M; Department of Psychology, San Diego State University., Kraus B; Department of Psychology, Northwestern University, Evanston Campus., Glazer J; Department of Psychology, Northwestern University, Evanston Campus., Nusslock R; Department of Psychology, Northwestern University, Evanston Campus., Kappenman ES; Department of Psychology, San Diego State University., Mittal VA; Department of Psychology, Northwestern University, Evanston Campus. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of psychopathology and clinical science [J Psychopathol Clin Sci] 2022 May; Vol. 131 (4), pp. 375-391. |
| DOI: |
10.1037/abn0000754 |
| Abstrakt: |
Motor abnormalities are a core feature of psychotic disorders observed from the premorbid period through chronic illness, suggesting motor dysfunction may reflect the pathophysiology of psychosis. Electrophysiology research in schizophrenia suggests impaired motor activation and preparation may underlie these motor abnormalities. Despite behavioral studies suggesting similar motor dysfunction in those at clinical high-risk (CHR) for psychosis, there have been no studies examining neural mechanisms of motor dysfunction in the CHR period, where research can inform pathophysiological and risk models. The present study used the lateralized readiness potential (LRP), an event-related potential index of motor activation and preparation, to examine mechanisms of motor dysfunction in 42 CHR and 41 control participants (N = 83, 56% female). Response competition was manipulated to determine whether deficits are secondary to cognitive control impairments or reflect primary motor deficits. Behaviorally, CHR participants exhibited overall slower responses than controls. Further, relative to controls, CHR participants showed reduced activation of correct but not incorrect responses, reflected in blunted LRP amplitude under weak response competition and no difference in amplitude associated with the incorrect response under strong response competition. This pattern of results suggests individuals at CHR for psychosis exhibit primary motor deficits in activating and preparing behavioral responses and are contrary to a deficit in cognitive control. Further, blunted LRP amplitude was associated with worsening of negative symptoms at 12-month follow-up. Together, these findings are consistent with LRP studies in psychosis and implicate motor activation deficits as potential mechanisms of motor dysfunction in the high-risk period. (PsycInfo Database Record (c) 2022 APA, all rights reserved). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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