Natural, synthetic and commercially-available biopolymers used to regenerate tendons and ligaments.

Autor:	Shiroud Heidari B; Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, QEII Medical Centre and the UWA Centre for Medical Research, The University of Western Australia, Nedlands, 6009, Australia.; School of Engineering, The University of Western Australia, Perth, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia., Ruan R; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia.; Division of Surgery (Orthopaedics), Medical School, The University of Western Australia, Perth, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia., Vahabli E; Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, QEII Medical Centre and the UWA Centre for Medical Research, The University of Western Australia, Nedlands, 6009, Australia.; School of Engineering, The University of Western Australia, Perth, Australia., Chen P; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia.; Division of Surgery (Orthopaedics), Medical School, The University of Western Australia, Perth, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia., De-Juan-Pardo EM; School of Engineering, The University of Western Australia, Perth, Australia.; T3mPLATE, Harry Perkins Institute of Medical Research, QEII Medical Centre and the UWA Centre for Medical Research, The University of Western Australia, Nedlands, 6009, Australia.; Science and Engineering Faculty, Queensland University of Technology, Brisbane, Queensland, Australia., Zheng M; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia.; Division of Surgery (Orthopaedics), Medical School, The University of Western Australia, Perth, Australia.; Perron Institute for Neurological and Translational Science, Nedlands, 6009, Australia., Doyle B; Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, QEII Medical Centre and the UWA Centre for Medical Research, The University of Western Australia, Nedlands, 6009, Australia.; School of Engineering, The University of Western Australia, Perth, Australia.; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia.; BHF Centre for Cardiovascular Science, The University of Edinburgh, UK.
Jazyk:	angličtina
Zdroj:	Bioactive materials [Bioact Mater] 2022 Apr 13; Vol. 19, pp. 179-197. Date of Electronic Publication: 2022 Apr 13 (Print Publication: 2023).
DOI:	10.1016/j.bioactmat.2022.04.003
Abstrakt:	Tendon and ligament (TL) injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair, whether the treatment relies on tissue engineering strategies or using artificial tendon grafts. The biopolymer governs the mechanical properties, biocompatibility, degradation, and fabrication method of the TL scaffold. Many natural, synthetic and hybrid biopolymers have been studied in TL regeneration, often combined with therapeutic agents and minerals to engineer novel scaffold systems. However, most of the advanced biopolymers have not advanced to clinical use yet. Here, we aim to review recent biopolymers and discuss their features for TL tissue engineering. After introducing the properties of the native tissue, we discuss different types of natural, synthetic and hybrid biopolymers used in TL tissue engineering. Then, we review biopolymers used in commercial absorbable and non-absorbable TL grafts. Finally, we explain the challenges and future directions for the development of novel biopolymers in TL regenerative treatment. Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Minghao Zheng is consultant to Orthocell Ltd and hold stock in the company. (© 2022 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu