Haematological, Biochemical, and Inflammatory Biomarkers of COVID-19 Patients Hospitalized in Critical Unit: A Retrospective Study.

Autor:	Alsafi RT; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, SAU., Minshawi F; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, SAU., Alshareef A; Clinical Molecular Department, Regional Laboratory in Makkah, Ministry of Health, Mecca, SAU., Althobiany E; Laboratory and Blood Bank, Al Noor Specialist Hospital, Ministry of Health, Mecca, SAU., Alqurashi A; Molecular Biology, Independent Researcher, Mecca, SAU., Zawawi A; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, SAU., Qasem A; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, SAU., Halawani AJ; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, SAU., Almatrafi M; Department of Pediatrics, Umm Al-Qura University, Mecca, SAU., Alwafi H; Pharmacology and Therapeutics, Umm Al-Qura University, Mecca, SAU., Samannodi M; Department of Medicine, Faculty of Medicine, Umm Al-Qura University, Mecca, SAU., Salawati E; Family Medicine, King Abdulaziz University, Jeddah, SAU., Assaggaf HM; Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Mecca, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2022 Mar 31; Vol. 14 (3), pp. e23691. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
DOI:	10.7759/cureus.23691
Abstrakt:	Background: The World Health Organization declared coronavirus disease 2019 (COVID-19) responsible for a catastrophic global pandemic. The complexity of COVID-19 is centred on the unpredictable course of the disease, which can rapidly develop from patients being asymptomatic to having life-threatening symptoms. The unpredictable disease severity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major problem facing the healthcare system during the pandemic. Identifying the laboratory biomarkers would help predict SARS-CoV-2 pathogenicity. This study focused on the previous literature regarding three laboratory biomarker profiles: haematological, inflammatory, and biochemical biomarkers. Methods: A retrospective study of COVID-19 patients was conducted between May 2020 and September 2020 to determine the predictors of hospitalization (severity) in COVID-19 patients. Patients were divided into two groups: those admitted to an intensive care unit (ICU, severe) and those admitted to a non-ICU (stable). Patients' data were obtained from their medical records at Al Noor Specialist Hospital and East Arafat Hospital in Saudi Arabia. Results: A total of 487 patients with COVID-19, including 304 males and 183 females, were investigated in this study. A total of 217 patients were admitted to the ICU. Patients admitted to the ICU had a higher prevalence of chronic comorbidities than non-ICU patients. D-dimer, white blood cells (WBC), neutrophils, ferritin, C-reactive protein (CRP), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were more elevated in patients admitted to the ICU compared to non-ICU patients. Conclusion: Chronic comorbidities are a significant predictor for admission to the ICU. Moreover, tests for D-dimer, WBC, neutrophils, lymphocytes, CRP, LDH, and ALT could be used to predict patients' admission to the ICU. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2022, Alsafi et al.)
Databáze:	MEDLINE
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