Reawakening GDNF's regenerative past in mice and humans.

Autor:	Samos A; University of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USA., McGaughey V; University of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USA., Rieger S; University of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA., Lisse TS; University of Miami, Biology Department, 1301 Memorial Drive, Cox Science Center, Coral Gables, FL, USA.; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL, USA.
Jazyk:	angličtina
Zdroj:	Regenerative therapy [Regen Ther] 2022 Apr 19; Vol. 20, pp. 78-85. Date of Electronic Publication: 2022 Apr 19 (Print Publication: 2022).
DOI:	10.1016/j.reth.2022.03.008
Abstrakt:	The ability of an animal to regenerate lost tissue and body parts has obviously life-saving implications. Understanding how this ability became restricted or active in specific animal lineages will help us understand our own regeneration. According to phylogenic analysis, the glial cell line-derived neurotrophic factor (GDNF) signaling pathway, but not other family members, is conserved in axolotls, a salamander with remarkable regenerative capacity. Furthermore, comparing the pro-regenerative Spiny mouse to its less regenerative descendant, the House mouse, revealed that the GDNF signaling pathway, but not other family members, was induced in regenerating Spiny mice. According to GDNF receptor expression analysis, GDNF may promote hair follicle neogenesis - an important feature of skin regeneration - by determining the fate of dermal fibroblasts as part of new hair follicles. These findings support the idea that GDNF treatment will promote skin regeneration in humans by demonstrating the GDNF signaling pathway's ancestral and cellular nature. Competing Interests: The authors have no conflict interests to declare. (© 2022 The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.)
Databáze:	MEDLINE
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