Does being infected with SARS-CoV-2 in the first-trimester increase the risk of miscarriage?

Autor: Kiremitli S; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Kiremitli T; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Ulug P; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Kirkinci A; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Kurnuc FZ; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Yilmaz N; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Dinc K; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Yilmaz BK; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Gul OI; Erzincan Binali Yildirim University, Medical Faculty, Infectious Diseases Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey., Uzel K; Erzincan Binali Yildirim University, Medical Faculty, Obstetrics and Gynaecology Department, Basbaglar District, Haci Ali Akin Street, 32, 24100, Center, Erzincan, Turkey.
Jazyk: angličtina
Zdroj: Anais da Academia Brasileira de Ciencias [An Acad Bras Cienc] 2022 May 02; Vol. 94 (2), pp. e20211283. Date of Electronic Publication: 2022 May 02 (Print Publication: 2022).
DOI: 10.1590/0001-3765202220211283
Abstrakt: Aim of this study is to investigate whether the risk of miscarriage increases in pregnant women who had COVID-19 in first trimester. Our study included 52 patients with SARS-CoV-2 infection detected by RT-PCR and 53 patients with negative RT-PCR test in samples taken with nasopharyngeal swab in the first trimester between March 1 and December 31, 2020. Complete abortion, incomplete abortion, blighted ovum, intrauterine exitus, biochemical pregnancies were accepted as in the miscarriage group (MG). Pregnant women with COVID-19 and control group were compared in terms of demographic data, miscarriage rate and laboratory results. Patients were divided into MG and ongoing pregnancy groups (OPG) and compared in terms of the diagnosed weeks, clinical findings, laboratory results, treatments, and hospitalization. While miscarriage was observed in 15 (28.8%) of pregnant women infected with SARS-CoV-2 in the first trimester, this number was 7 (13.2%) in the control group. While the common symptoms in the MG were cough (60%), fever (53.3%), shortness of breath (53.3%), and fatigue (46.7%) (p<0.05); asymptomatic patients (51.4%) were higher in the OPG (p<0.001). Hospitalized patients were 33.3% in the MG and 8.1% in the OPG (p=0.02). According to the results of our study, the risk of miscarriage increases in pregnant women infected with SARS-CoV-2 (especially in severe infection) in the first trimester.
Databáze: MEDLINE