Large-scale mitogenome sequencing reveals consecutive expansions of domestic taurine cattle and supports sporadic aurochs introgression.

Autor: Cubric-Curik V; Department of Animal Science University of Zagreb Faculty of Agriculture Zagreb Croatia., Novosel D; Department of Animal Science University of Zagreb Faculty of Agriculture Zagreb Croatia.; Department of Pathology Croatian Veterinary Institute Zagreb Croatia., Brajkovic V; Department of Animal Science University of Zagreb Faculty of Agriculture Zagreb Croatia., Rota Stabelli O; Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre Fondazione Edmund Mach S. Michele all' Adige Italy., Krebs S; Laboratory for Functional Genome Analysis Gene Center Ludwig Maximilians University Munich Munich Germany., Sölkner J; Division of Livestock Sciences Department of Sustainable Agricultural Systems BOKU-University of Natural Resources and Life Sciences Vienna Vienna Austria., Šalamon D; Department of Animal Science University of Zagreb Faculty of Agriculture Zagreb Croatia., Ristov S; Ruđer Bošković Institute Zagreb Croatia., Berger B; AREC Raumberg-Gumpenstein Institute of Organic Farming and Biodiversity of Farm Animals Thalheim Austria., Trivizaki S; Institute of Animal Genetic Resources Nea Mesimvria Thessaloniki Greece., Bizelis I; Faculty of Animal Science and Aquaculture Department of Animal Breeding & Husbandry Agricultural University of Athens Athens Greece., Ferenčaković M; Department of Animal Science University of Zagreb Faculty of Agriculture Zagreb Croatia., Rothammer S; Population Genomics Group Faculty of Veterinary Medicine Department of Veterinary Sciences LMU Munich Munich Germany., Kunz E; Population Genomics Group Faculty of Veterinary Medicine Department of Veterinary Sciences LMU Munich Munich Germany., Simčič M; Biotechnical Faculty Department of Animal Science University of Ljubljana Ljubljana Slovenia., Dovč P; Biotechnical Faculty Department of Animal Science University of Ljubljana Ljubljana Slovenia., Bunevski G; Faculty of Agricultural Sciences and Food University Ss. Cyril and Methodius Skopje Macedonia., Bytyqi H; Faculty of Agriculture and Veterinary Department of Animal Science University of Prishtina Prishtina Kosovo., Marković B; Biotechnical Faculty Department of Livestock Science University of Montenegro Podgorica Montenegro., Brka M; Faculty of Agriculture and Food Science Institute of Animal Sciences University of Sarajevo Sarajevo Bosnia and Herzegovina., Kume K; ALBAGENE Association Tirana Albania., Stojanović S; Ministry of Agriculture, Forestry and Water Management Beograd Serbia., Nikolov V; Executive Agency for Selection and Reproduction in Animal Breeding Sofia Bulgaria., Zinovieva N; Center of Biotechnology and Molecular Diagnostics of the L.K. Ernst Institute of Animal Husbandry Moscow Region Russia., Schönherz AA; Department of Animal Science Aarhus University Tjele Denmark., Guldbrandtsen B; Department of Animal Sciences Rheinische Friedrich-Wilhelms-Universität Bonn Bonn Germany., Čačić M; Croatian Agricultural Agency Zagreb Croatia., Radović S; Institute for Quaternary Palaeontology and Geology Croatian Academy of Sciences and Arts Zagreb Croatia., Miracle P; Department of Archaeology University of Cambridge Cambridge UK., Vernesi C; Department of Sustainable Agro-Ecosystems and Bioresources, Research and Innovation Centre Fondazione Edmund Mach S. Michele all' Adige Italy., Curik I; Department of Animal Science University of Zagreb Faculty of Agriculture Zagreb Croatia., Medugorac I; Population Genomics Group Faculty of Veterinary Medicine Department of Veterinary Sciences LMU Munich Munich Germany.
Jazyk: angličtina
Zdroj: Evolutionary applications [Evol Appl] 2021 Nov 27; Vol. 15 (4), pp. 663-678. Date of Electronic Publication: 2021 Nov 27 (Print Publication: 2022).
DOI: 10.1111/eva.13315
Abstrakt: The contribution of domestic cattle in human societies is enormous, making cattle, along with other essential benefits, the economically most important domestic animal in the world today. To expand existing knowledge on cattle domestication and mitogenome diversity, we performed a comprehensive complete mitogenome analysis of the species (802 sequences, 114 breeds). A large sample was collected in South-east Europe, an important agricultural gateway to Europe during Neolithization and a region rich in cattle biodiversity. We found 1725 polymorphic sites (810 singletons, 853 parsimony-informative sites and 57 indels), 701 unique haplotypes, a haplotype diversity of 0.9995 and a nucleotide diversity of 0.0015. In addition to the dominant T 3 and several rare haplogroups (Q, T 5 , T 4 , T 2 and T 1 ), we have identified maternal line in Austrian Murbodner cattle that possess surviving aurochs' mitochondria haplotype P 1 that diverged prior to the Neolithization process. This is convincing evidence for rare female-mediated adaptive introgression of wild aurochs into domesticated cattle in Europe. We revalidated the existing haplogroup classification and provided Bayesian phylogenetic inference with a more precise estimated divergence time than previously available. Occasionally, classification based on partial mitogenomes was not reliable; for example, some individuals with haplogroups P and T 5 were not recognized based on D-loop information. Bayesian skyline plot estimates (median) show that the earliest population growth began before domestication in cattle with haplogroup T 2 , followed by Q (~10.0-9.5 kyBP), whereas cattle with T 3 (~7.5 kyBP) and T 1 (~3.0-2.5 kyBP) expanded later. Overall, our results support the existence of interactions between aurochs and cattle during domestication and dispersal of cattle in the past, contribute to the conservation of maternal cattle diversity and enable functional analyses of the surviving aurochs P 1  mitogenome.
Competing Interests: None declared.
(© 2021 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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