Neonatal injury models: integral tools to decipher the molecular basis of cardiac regeneration.

Autor: Costa A; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.; REBIRTH-Centre for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany., Cushman S; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany., Haubner BJ; Department of Internal Medicine III (Cardiology and Angiology), Innsbruck Medical University, Innsbruck, Austria.; Department of Cardiology, University Heart Center, University Hospital Zurich, Zürich, Switzerland., Derda AA; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Thum T; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany.; REBIRTH-Centre for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany., Bär C; Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, Hannover, Germany. baer.christian@mh-hannover.de.; REBIRTH-Centre for Translational Regenerative Medicine, Hannover Medical School, Hannover, Germany. baer.christian@mh-hannover.de.; Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), Hannover, Germany. baer.christian@mh-hannover.de.
Jazyk: angličtina
Zdroj: Basic research in cardiology [Basic Res Cardiol] 2022 May 03; Vol. 117 (1), pp. 26. Date of Electronic Publication: 2022 May 03.
DOI: 10.1007/s00395-022-00931-w
Abstrakt: Myocardial injury often leads to heart failure due to the loss and insufficient regeneration of resident cardiomyocytes. The low regenerative potential of the mammalian heart is one of the main drivers of heart failure progression, especially after myocardial infarction accompanied by large contractile muscle loss. Preclinical therapies for cardiac regeneration are promising, but clinically still missing. Mammalian models represent an excellent translational in vivo platform to test drugs and treatments for the promotion of cardiac regeneration. Particularly, short-lived mice offer the possibility to monitor the outcome of such treatments throughout the life span. Importantly, there is a short period of time in newborn mice in which the heart retains full regenerative capacity after cardiac injury, which potentially also holds true for the neonatal human heart. Thus, in vivo neonatal mouse models of cardiac injury are crucial to gain insights into the molecular mechanisms underlying the cardiac regenerative processes and to devise novel therapeutic strategies for the treatment of diseased adult hearts. Here, we provide an overview of the established injury models to study cardiac regeneration. We summarize pioneering studies that demonstrate the potential of using neonatal cardiac injury models to identify factors that may stimulate heart regeneration by inducing endogenous cardiomyocyte proliferation in the adult heart. To conclude, we briefly summarize studies in large animal models and the insights gained in humans, which may pave the way toward the development of novel approaches in regenerative medicine.
(© 2022. The Author(s).)
Databáze: MEDLINE
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