Panel of Candidate Genes to Predict the Survival of Patients with Clear Cell Renal Cancer on the Basis of Gene Expression Regulated by HIF1α/HIF2α.

Autor: Apanovich NV; N. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia., Apanovich PV; N. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia., Mansorunov DJ; N. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia., Kuzevanova AY; N. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia., Korotaeva AA; N. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia., Bogush TA; N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia., Matveev VB; N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russia., Karpukhin AV; N. P. Bochkov Research Centre for Medical Genetics, Moscow, Russia. karpukhin@med-gen.ru.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 Apr; Vol. 172 (6), pp. 738-742. Date of Electronic Publication: 2022 May 02.
DOI: 10.1007/s10517-022-05468-5
Abstrakt: The detection of genes related to the lifetime of patients with clear cell renal cancer provides information on the mechanisms of the tumor development and can be the basis for creating approaches to predict patient survival. In this paper, the expression of genes regulated by the HIF2α transcriptional factor was studied. Based on the results obtained here and previously identified genes regulated by the transcriptional factor HIF1α, a new panel of 6 genes, including the BAP1 gene, was proposed. Expression of genes of this panel allows predicting the survival of patients with clear cell renal cancer with high sensitivity (93%), specificity (96%), and relative risk (21.5). After verification, the application of this panel can be useful for personalized treatment of patients with clear cell renal cancer, which will increase the effectiveness of therapy.
(© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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