The 4D Nucleome Data Portal as a resource for searching and visualizing curated nucleomics data.

Autor: Reiff SB; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Schroeder AJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Kırlı K; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Cosolo A; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Bakker C; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Mercado L; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Lee S; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Veit AD; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Balashov AK; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Vitzthum C; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Ronchetti W; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Pitman KM; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Johnson J; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Ehmsen SR; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Kerpedjiev P; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Abdennur N; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Imakaev M; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Öztürk SU; Karya SMD Software Solutions, İzmir, 35040, Turkey., Çamoğlu U; Karya SMD Software Solutions, İzmir, 35040, Turkey., Mirny LA; Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.; Department of Physics, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA., Gehlenborg N; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Alver BH; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA., Park PJ; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, 02115, USA. peter_park@hms.harvard.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 May 02; Vol. 13 (1), pp. 2365. Date of Electronic Publication: 2022 May 02.
DOI: 10.1038/s41467-022-29697-4
Abstrakt: The 4D Nucleome (4DN) Network aims to elucidate the complex structure and organization of chromosomes in the nucleus and the impact of their disruption in disease biology. We present the 4DN Data Portal ( https://data.4dnucleome.org/ ), a repository for datasets generated in the 4DN network and relevant external datasets. Datasets were generated with a wide range of experiments, including chromosome conformation capture assays such as Hi-C and other innovative sequencing and microscopy-based assays probing chromosome architecture. All together, the 4DN data portal hosts more than 1800 experiment sets and 36000 files. Results of sequencing-based assays from different laboratories are uniformly processed and quality-controlled. The portal interface allows easy browsing, filtering, and bulk downloads, and the integrated HiGlass genome browser allows interactive visualization and comparison of multiple datasets. The 4DN data portal represents a primary resource for chromosome contact and other nuclear architecture data for the scientific community.
(© 2022. The Author(s).)
Databáze: MEDLINE
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