Association of the Combined Effects between Insulin-Like Growth Factor-1 Gene Polymorphisms and Negative Life Events with Major Depressive Disorder among Chinese population in the Context of Oxidative Stress.

Autor: Qiao Z; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Xie Y; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Wu Y; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Yang X; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Qiu X; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Zhou J; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Lu Y; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Chen L; Beijing Hospital, Beijing, China., Tong Y; Department of Psychology, School of Education of Heilongjiang University, Harbin, Heilongjiang Province, China., Xu J; The First Psychiatric Hospital of Harbin, Heilongjiang Province, China., Li J; Department of Medical Education Management, Harbin Medical University, Harbin, China., He J; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Pan H; Department of Endocrinology, Peking Union Medical College Hospital, Beijing, China., Yang Y; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China., Yang J; Department of Psychology, School of Education of Heilongjiang University, Harbin, Heilongjiang Province, China., Bu T; Department of Medical Psychology, Harbin Medical University, Harbin, Heilongjiang Province, China.
Jazyk: angličtina
Zdroj: Oxidative medicine and cellular longevity [Oxid Med Cell Longev] 2022 Apr 22; Vol. 2022, pp. 3253687. Date of Electronic Publication: 2022 Apr 22 (Print Publication: 2022).
DOI: 10.1155/2022/3253687
Abstrakt: Background: Oxidative stress may be increased in a number of psychiatric disorders, including major depressive disorder (MDD). MDD has been shown to be related to insulin-like growth factor-1 (IGF-1) as well as to negative life events; exploring the interaction of IGF-1 polymorphisms and negative life events on the risk of MDD is needed. The aim of this study was to analyze the single and combined effects of IGF-1 polymorphisms (rs972936 and rs978458) and negative life events with MDD among Chinese population.
Methods: 420 MDD patients (according to DSM-V) and 420 age- and gender-matched control subjects were recruited in a case-control study. Negative life events were assessed using standard rating scales. IGF-1 rs972936 and rs978458 were identified by sequencing. The chi-square ( χ 2 ) tests were performed to explore the association of negative life events and IGF-1 polymorphisms with MDD.
Results: Our results found that the negative life events were associated with the risk of MDD ( P < 0.001; OR = 3.28, 95% CI: 2.19-4.85). The genotypes of IGF-1 were associated with the risk of MDD ( P < 0.001); carrying the IGF-1 rs972936 C allele (OR = 1.53, 95% CI: 1.26-1.85) and rs978458 T allele (OR = 1.92, 95% CI: 1.58-2.34) had a higher risk of MDD. The combined effects between IGF-1 rs978458 and negative life events were associated with the risk of MDD ( P < 0.05; OR = 2.94, 95% CI: 1.23-7.03), but IGF-1 rs972936 was not associated ( P > 0.05).
Conclusions: Based on the oxidative stress hypothesis, we confirm that carrying IGF-1 rs972936 C allele and rs978458 T allele have a higher risk of MDD and the combined effects between IGF-1 rs978458 and negative life events were associated with the risk of MDD among Chinese population.
Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this paper.
(Copyright © 2022 Zhengxue Qiao et al.)
Databáze: MEDLINE
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