Chronic Exposure to Dim Light at Night or Irregular Lighting Conditions Impact Circadian Behavior, Motor Coordination, and Neuronal Morphology.

Autor:	Delorme TC; Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada., Srikanta SB; Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada., Fisk AS; Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, United Kingdom., Cloutier MÈ; Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada., Sato M; Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Pothecary CA; Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, United Kingdom., Merz C; Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Foster RG; Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, United Kingdom., Brown SA; Chronobiology and Sleep Research Group, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland., Peirson SN; Nuffield Department of Clinical Neurosciences, Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, United Kingdom., Cermakian N; Department of Psychiatry, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada., Banks GT; Mammalian Genetics Unit, MRC Harwell Institute, Oxfordshire, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2022 Apr 13; Vol. 16, pp. 855154. Date of Electronic Publication: 2022 Apr 13 (Print Publication: 2022).
DOI:	10.3389/fnins.2022.855154
Abstrakt:	Mistimed exposure to light has been demonstrated to negatively affect multiple aspects of physiology and behavior. Here we analyzed the effects of chronic exposure to abnormal lighting conditions in mice. We exposed mice for 1 year to either: a standard light/dark cycle, a "light-pollution" condition in which low levels of light were present in the dark phase of the circadian cycle (dim light at night, DLAN), or altered light cycles in which the length of the weekday and weekend light phase differed by 6 h ("social jetlag"). Mice exhibited several circadian activity phenotypes, as well as changes in motor function, associated particularly with the DLAN condition. Our data suggest that these phenotypes might be due to changes outside the core clock. Dendritic spine changes in other brain regions raise the possibility that these phenotypes are mediated by changes in neuronal coordination outside of the clock. Given the prevalence of artificial light exposure in the modern world, further work is required to establish whether these negative effects are observed in humans as well. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Delorme, Srikanta, Fisk, Cloutier, Sato, Pothecary, Merz, Foster, Brown, Peirson, Cermakian and Banks.)
Databáze:	MEDLINE
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