Litoarbolide A: an undescribed sesquiterpenoid from the Red Sea soft coral Litophyton arboreum with an in vitro anti-malarial activity evaluation.

Autor: Ahmed MMA; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi, United States.; Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, United States., Ragab EA; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Zayed A; Department of Pharmacognosy, Tanta University, College of Pharmacy, Tanta, Egypt.; Institute of Bioprocess Engineering, Technical University of Kaiserslautern, Kaiserslautern, Germany., El-Ghaly EM; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Ismail SK; Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt., Khan SI; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi, United States.; Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, United States., Ali Z; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi, United States., Chittiboyina AG; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi, United States., Khan IA; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, Mississippi, United States.; Division of Pharmacognosy, Department of Biomolecular Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi, United States.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2023 Feb; Vol. 37 (4), pp. 542-550. Date of Electronic Publication: 2022 May 02.
DOI: 10.1080/14786419.2022.2071268
Abstrakt: Soft corals distributed across the Red Sea coasts are a rich source of diverse and bioactive natural products. Chemical probing of the Red Sea soft coral Litophyton arboreum led to isolation and structural characterization of an undescribed sesquiterpenoid, litoarbolide A ( 1 ), along with 14 previously reported metabolites ( 2-15 ). The chemical structures of the isolates were assigned based on NMR as well as high resolution electrospray ionization mass spectrometry (HR-ESI-MS) data. Litoarbolide A is supposed to be the biosynthetic precursor to other sesquiterpenoids, which formed via further post-translational modifications. Furthermore, these metabolites were evaluated for anti-malarial activity, where only the acyclic sesquiterpenoid of a sec -germacrane nucleus ( 7 ) showed an activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC 50 at 3.7 and 2.2 mg/mL, respectively. Moreover, the isolated metabolites were all non-toxic to the Vero cell line. These findings support the consideration of L. arboreum in further natural anti-malarial studies.
Databáze: MEDLINE