Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units.

Autor:	Torres A; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Department of Pneumology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute-IDIBAPS, University of Barcelona, Barcelona, Spain. Electronic address: atorres@clinic.cat., Motos A; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Department of Pneumology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute-IDIBAPS, University of Barcelona, Barcelona, Spain., Ceccato A; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Department of Pneumology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute-IDIBAPS, University of Barcelona, Barcelona, Spain., Bermejo-Martin J; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Group for Biomedical Research in Sepsis (BioSepsis), Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Hospital Universitario Río Hortega de Valladolid, Valladolid, Spain., de Gonzalo-Calvo D; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Translational Research in Respiratory Medicine, Respiratory Department, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain., Pérez R; Barcelona Supercomputing Centre (BSC), Barcelona, Spain., Barroso M; Barcelona Supercomputing Centre (BSC), Barcelona, Spain., Pascual IZ; Ubikare Technology, Vizcaya, Spain., Gonzalez J; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Department of Pneumology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute-IDIBAPS, University of Barcelona, Barcelona, Spain; Group for Biomedical Research in Sepsis (BioSepsis), Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain; Hospital Universitario Río Hortega de Valladolid, Valladolid, Spain; Intensive Care Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Barcelona, Spain; Barcelona Supercomputing Centre (BSC), Barcelona, Spain; Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain; Translational Research in Respiratory Medicine, Respiratory Department, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain., Fernández-Barat L; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Department of Pneumology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute-IDIBAPS, University of Barcelona, Barcelona, Spain., Ferrer R; Intensive Care Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Barcelona, Spain., Riera J; Intensive Care Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca, Barcelona, Spain., García-Gasulla D; Barcelona Supercomputing Centre (BSC), Barcelona, Spain., Peñuelas O; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain., Lorente JÁ; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Hospital Universitario de Getafe, Universidad Europea, Madrid, Spain., Almansa R; Group for Biomedical Research in Sepsis (BioSepsis), Instituto de Investigación Biomédica de Salamanca (IBSAL), Salamanca, Spain., Menéndez R; Pulmonary Department, University and Polytechnic Hospital La Fe, Valencia, Spain., Kiarostami K; Department of Pneumology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute-IDIBAPS, University of Barcelona, Barcelona, Spain., Canseco J; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Department of Pneumology, Hospital Clínic of Barcelona, August Pi i Sunyer Biomedical Research Institute-IDIBAPS, University of Barcelona, Barcelona, Spain., Villar RA; Intensive Care Clinical Unit, Hospital Universitario Virgen de Rocío, Sevilla, Spain., Añón JM; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Servicio de Medicina Intensiva, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain., Mariño AB; Hospital Universitario San Agustín, Avilés, Asturias, Spain., Barberà C; Hospital Santa Maria, IRBLleida, Lleida, Spain., Barberán J; Hospital Universitario HM Montepríncipe, Universidad San Pablo-CEU, Madrid, Spain., Ortiz AB; Servicio de Medicina Intensiva, Hospital Universitario Ramón y Cajal, Madrid, Spain., Boado MV; Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain., Bustamante-Munguira E; Department of Intensive Care Medicine, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Caballero J; Critical Care Department, Hospital Universitari Arnau de Vilanova, IRBLleida, Lleida, Spain., Cantón-Bulnes ML; Intensive Care Clinical Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain., Pérez CC; Intensive Care Unit, Hospital Álvaro Cunqueiro, Vigo, Pontevedra, Spain., Carbonell N; Intensive Care Unit, Hospital Clínico y Universitario de Valencia, Valencia, Spain., Catalán-González M; Department of Intensive Care Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain., de Frutos R; Servicio de Anestesiología y Reanimación, Hospital Universitario de Basurto, Bilbao, Vizcaya, Spain., Franco N; Hospital Universitario de Móstoles, Madrid, Spain., Galbán C; Department of Medicine, CHUS, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela, A Coruña, Spain., Gumucio-Sanguino VD; Department of Intensive Care, Hospital Universitari de Bellvitge, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain., Torre MDC; Hospital de Mataró, Barcelona, Spain., Díaz E; Critical Care Department, Corporació Sanitària Parc Taulí, Department of Medicine, Universitat Autònoma de Barcelona (UAB), Sabadell, Barcelona, Spain., Estella Á; Departamento de Medicina, Facultad de Medicina, Universidad de Cádiz, Hospital Universitario de Jerez, Jerez de la Frontera, Cádiz, Spain., Gallego E; Unidad de Cuidados Intensivos, Hospital Universitario San Pedro de Alcántara, Cáceres, Spain., Garmendia JLG; Intensive Care Unit, Hospital San Juan de Dios del Aljarafe, Bormujos, Sevilla, Spain., Gómez JM; Hospital General Universitario Gregorio Marañón, Madrid, Spain., Huerta A; Pulmonary and Critical Care Division, Emergency Department, Clínica Sagrada Família, Barcelona, Spain., García RNJ; Intensive Care Department, Hospital Nuestra Señora de Gracia, Zaragoza, Spain., Loza-Vázquez A; Unidad de Medicina Intensiva, Hospital Universitario Virgen de Valme, Sevilla, Spain., Marin-Corral J; Critical Care Department, Hospital del Mar-IMIM, Barcelona, Spain., Delgado MCM; Hospital Universitario de Torrejón-Universidad Francisco de Vitoria, Madrid, Spain., Gándara AM; Department of Intensive Medicine, Hospital Universitario Infanta Leonor, Madrid, Spain., Varela IM; Critical Care Department, Hospital Universitario Lucus Augusti, Lugo, Spain., Messa JL; Complejo Asistencial Universitario de Palencia, Palencia, Spain., Albaiceta GM; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Hospital Central de Asturias, Oviedo, Asturias, Spain., Nieto M; Hospital Universitario de Segovia, Segovia, Spain., Novo MA; Servei de Medicina Intensiva, Hospital Universitari Son Espases, Palma de Mallorca, Illes Balears, Spain., Peñasco Y; Servicio de Medicina Intensiva, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain., Pérez-García F; Servicio de Microbiología Clínica, Hospital Universitario Príncipe de Asturias, Departamento de Biomedicina y Biotecnología, Universidad de Alcalá de Henares, Madrid, Spain., Pozo-Laderas JC; UGC-Medicina Intensiva, Hospital Universitario Reina Sofía, Instituto Maimónides IMIBIC, Córdoba, Spain., Ricart P; Servei de Medicina Intensiva, Hospital Universitari Germans Trias, Badalona, Barcelona, Spain., Sagredo V; Hospital Universitario de Salamanca, Salamanca, Spain., Sánchez-Miralles Á; Hospital de Sant Joan d'Alacant, Sant Joan d'Alacant, Alacant, Spain., Chinesta SS; Servicio de Medicina Intensiva, Hospital Universitario y Politécnico La Fe, Valencia, Spain., Serra-Fortuny M; Pneumology Department, Hospital Verge de la Cinta, Tortosa, Tarragona, Spain., Socias L; Intensive Care Unit, Hospital Son Llàtzer, Palma de Mallorca, Illes Balears, Spain., Solé-Violan J; Critical Care Department, Hospital de Gran Canaria Dr. Negrín, Las Palmas, Spain., Suárez-Sipmann F; Intensive Care Unit, Hospital Universitario de La Princesa, Madrid, Spain., Lomas LT; Critical Care Department, Hospital Universitario Río Hortega de Valladolid, Valladolid, Spain., Trenado J; Servicio de Medicina Intensiva, Hospital Universitario Mútua de Terrassa, Terrassa, Barcelona, Spain., Úbeda A; Servicio de Medicina Intensiva, Hospital Punta de Europa, Algeciras, Cádiz, Spain., Valdivia LJ; Hospital Universitario de León, León, Spain., Vidal P; Complexo Hospitalario Universitario de Ourense, Ourense, Spain., Barbé F; CIBER de Enfermedades Respiratorias (CIBERES), Spain; Translational Research in Respiratory Medicine, Respiratory Department, Hospital Universitari Arnau de Vilanova and Santa Maria, IRBLleida, Lleida, Spain.
Jazyk:	English; Spanish; Castilian
Zdroj:	Archivos de bronconeumologia [Arch Bronconeumol] 2022 Apr; Vol. 58 Suppl 1, pp. 22-31. Date of Electronic Publication: 2022 Apr 15.
DOI:	10.1016/j.arbres.2022.03.010
Abstrakt:	Introduction: The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and other organ support with very high mortality. The Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call. Methods: CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality. Results: This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients. Conclusions: We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs. (Copyright © 2022. Published by Elsevier España, S.L.U.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu