Rhinovirus as the main co-circulating virus during the COVID-19 pandemic in children.

Autor:	Varela FH; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil., Sartor ITS; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Polese-Bonatto M; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Azevedo TR; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Kern LB; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Fazolo T; Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil., de David CN; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Zavaglia GO; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Fernandes IR; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Krauser JRM; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil., Stein RT; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil., Scotta MC; Social Responsibility, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil; Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: marcelo.scotta@hmv.org.br.
Jazyk:	angličtina
Zdroj:	Jornal de pediatria [J Pediatr (Rio J)] 2022 Nov-Dec; Vol. 98 (6), pp. 579-586. Date of Electronic Publication: 2022 Apr 19.
DOI:	10.1016/j.jped.2022.03.003
Abstrakt:	Objective: Changes in the epidemiology of respiratory infections during the restrictions imposed as a response to the coronavirus disease 2019 (COVID-19) pandemic have been reported elsewhere. The present study's aim was to describe the prevalence of a large array of respiratory pathogens in symptomatic children and adolescents during the pandemic in Southern Brazil. Methods: Hospitalized and outpatients aged 2 months to 18 years with signs and symptoms of acute COVID-19 were prospectively enrolled in the study from May to November 2020 in two hospitals in a large metropolitan area in a Brazilian city. All participants performed a real-time PCR panel assessing 20 respiratory pathogens (three bacteria and 17 viruses). Results: 436 participants were included, with 45 of these hospitalized. Rhinovirus was the most prevalent pathogen (216/436) followed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, 97/436), with a coinfection of these two viruses occurring in 31/436 participants. The remaining pathogens were found in 24 symptomatic participants (adenovirus, n = 6; Chlamydophila pneumoniae, n = 1; coronavirus NL63, n = 2; human enterovirus, n = 7; human metapneumovirus, n = 2; Mycoplasma pneumoniae, n = 6). Hospitalization was more common among infants (p = 0.004) and those with pathogens other than SARS-CoV-2 (p = 0.001). Conclusion: During the period of social distancing in response to COVID-19, the prevalence of most respiratory pathogens was unusually low. Rhinovirus remained as the main virus co-circulating with SARS-CoV-2. COVID-19 in symptomatic children was less associated with hospitalization than with other respiratory infections in children and adolescents. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (Copyright © 2022 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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