Chemical constituents from Pterocarpus santalinus and their inhibitory effects on nitric oxide production.

Autor: Han JS; College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea., Hong HR; College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea., Kim JG; College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea., Le TPL; College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea., Cho YB; College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea., Lee MK; College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea., Hwang BY; College of Pharmacy, Chungbuk National University, Cheongju 28610, Republic of Korea. Electronic address: byhwang@chungbuk.ac.kr.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2022 Jun; Vol. 159, pp. 105202. Date of Electronic Publication: 2022 Apr 28.
DOI: 10.1016/j.fitote.2022.105202
Abstrakt: A tropolone (2) and an acorane sesquiterpene (3), along with twenty previously known compounds were isolated from the heartwood of Pterocarpus santalinus. The structure of the isolated compounds was elucidated via 1D and 2D NMR spectroscopy and HRESIMS analysis. The absolute configuration of 3 was determined by comparison of the experimental and calculated ECD data. All compounds were evaluated for their inhibitory effects against nitric oxide production in LPS-stimulated RAW 264.7 macrophages.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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