Thrombotic and bleeding events, mortality, and anticoagulant use among 546,656 hospitalized patients with COVID-19 in the United States: a retrospective cohort study.

Autor: Deitelzweig S; Ochsner Clinic Foundation, Department of Hospital Medicine, Ochsner Medical Center, The University of Queensland School of Medicine, Ochsner Clinical School, 1514 Jefferson Hwy, New Orleans, LA, 70121, USA. sdeitelzweig@ochsner.org., Luo X; Pfizer Inc., Groton, CT, USA., Nguyen JL; Pfizer Inc., New York, NY, USA., Malhotra D; Pfizer Inc., New York, NY, USA., Emir B; Pfizer Inc., New York, NY, USA., Russ C; Pfizer Inc., New York, NY, USA., Li X; Bristol Myers Squibb Company, Lawrenceville, NJ, USA., Lee TC; Pfizer Inc., New York, NY, USA., Ferri M; Bristol Myers Squibb Company, Lawrenceville, NJ, USA., Wiederkehr D; Pfizer Inc., New York, NY, USA., Reimbaeva M; Pfizer Inc., Groton, CT, USA., Barnes GD; Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI, USA., Piazza G; Brigham and Women's Hospital, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2022 May; Vol. 53 (4), pp. 766-776. Date of Electronic Publication: 2022 Apr 30.
DOI: 10.1007/s11239-022-02644-2
Abstrakt: This study describes demographics, thrombotic and bleeding events, mortality, and anticoagulant use among hospitalized patients with COVID-19 in the United States. Premier Healthcare Database data were analyzed to identify inpatients with a discharge diagnosis for COVID-19 (ICD-10-CM code: U07.1) from April 1, 2020 to March 31, 2021, and matched historical controls without COVID-19 (inpatients discharged between April 1, 2018 and March 31, 2019). Thrombotic [including venous thromboembolism (VTE)] and bleeding events were based on ICD-10-CM discharge diagnosis codes. Of the 546,656 patients hospitalized with COVID-19, 20.1% were admitted to the ICU, 62.8% were aged ≥ 60 years, 51.5% were male, and 31.0% were non-white. Any thrombotic event was diagnosed in 10.0% of hospitalized and 20.8% of ICU patients with COVID-19 versus (vs) 11.5% and 24.4% for historical controls, respectively. More VTE events were observed in hospitalized and ICU patients with COVID-19 than historical controls (hospitalized: 4.4% vs 2.7%, respectively; ICU: 8.3% vs 5.2%, respectively; both P < 0.0001). Bleeding events were diagnosed in 10.2% of hospitalized and 21.8% of ICU patients with COVID-19 vs 16.0% and 33.2% for historical controls, respectively. Mortality among hospitalized (12.4%) and ICU (38.5%) patients with COVID-19 was higher vs historical controls (2.4%, P < 0.0001 and 9.4%, P < 0.0001, respectively) and higher in hospitalized patients with COVID-19 who had thrombotic events (29.4%) vs those without thrombotic events (10.8%, P < 0.0001). VTE and mortality were higher in hospitalized and ICU patients with COVID-19 vs historical controls. The presence of thrombotic events was associated with worse outcomes.
(© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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