Hibiscus sabdariffa extract improves hepatic steatosis, partially through IRS-1/Akt and Nrf2 signaling pathways in rats fed a high fat diet.

Autor: Prasomthong J; Department of Physiology, Faculty of Medical Science, Naresuan University, 99 Moo 9, Tahpoh, Muang, Phitsanulok, 65000, Thailand., Limpeanchob N; Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, 65000, Thailand.; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand., Daodee S; Division of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen, 40000, Thailand., Chonpathompikunlert P; Expert Center of Innovative Health Food (Innofood), Thailand Institute of Scientific and Technological Research (TISTR), Pathumthani, 12120, Thailand., Tunsophon S; Department of Physiology, Faculty of Medical Science, Naresuan University, 99 Moo 9, Tahpoh, Muang, Phitsanulok, 65000, Thailand. sakarat@nu.ac.th.; Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, 65000, Thailand. sakarat@nu.ac.th.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Apr 29; Vol. 12 (1), pp. 7022. Date of Electronic Publication: 2022 Apr 29.
DOI: 10.1038/s41598-022-11027-9
Abstrakt: Non-alcoholic fatty liver disease (NAFLD) has become a major world-wide health problem and is characterized by lipid accumulation in the liver induced by high fat diet (HFD) consumption. It is usually associated with inflammation, oxidative stress, and insulin resistance. Roselle extract (Hibiscus sabdariffa) is an herb which is used in traditional medicine. However, further study is necessary to represent the mechanism of NAFLD and find new preventive strategies. This study aims to investigate the protective effects of roselle extract on NAFLD rat models. Male Sprague-Dawley rats (n = 35) were divided into 5 groups, control, HFD, HFD + Simvastatin (HFD + SIM), HFD + 250 mg/kg BW, and HFD + 500 mg/kg BW of roselle extract (HFD + R250 and HFD + R500, respectively). The results showed that roselle extract reduced hepatic lipid contents, de novo lipogenesis enzymes, microsomal triglyceride transfer protein, inflammatory cytokines, malondialdehyde, and increased antioxidant properties, transporter related with lipoprotein uptake, and insulin signal proteins. Comparing to SIM, the HFD + R500 group exhibited the greater benefit in terms of anti-hepatic steatosis, antioxidant properties, and an ability to improve insulin resistance. This study demonstrates that roselle extract improved antioxidant properties and attenuated hepatic steatosis, liver inflammation, oxidative stress, and insulin resistance in HFD-induced NAFLD in rats, which could be used for NAFLD prevention.
(© 2022. The Author(s).)
Databáze: MEDLINE
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