Macroscopic Distribution, Histopathology and Viral Antigen Expression in Dogs with Canine Distemper Virus-induced Hyperkeratosis in Nasodigital and Other Regions.

Autor: Areco WVC; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Aguiar A; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Barraza V; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Fighera RA; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Kommers G; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Flores MM; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. Electronic address: marianamflores@yahoo.com.br., Flores EF; Department of Veterinary Preventive Medicine, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2022 May; Vol. 193, pp. 9-19. Date of Electronic Publication: 2022 Mar 22.
DOI: 10.1016/j.jcpa.2022.02.002
Abstrakt: Cutaneous hyperkeratosis is one of the many clinicopathological manifestations of canine distemper and is characterized by thickening and hardening of the skin, predominantly in nasodigital areas. Although this lesion may rarely affect other regions, this has been poorly characterized. Twelve dogs with canine distemper and cutaneous hyperkeratosis, necropsied at an anatomical pathology service, were investigated. Twenty-two cutaneous hyperkeratotic foci were observed on footpads (11/22), nasal planum (3/22), haired skin on the snout (2/22), periocular region (2/22), ventral abdomen (2/22), scrotum (1/22) and vulva (1/22). The dogs had one (5/12), two (4/12) or three (3/12) regions concomitantly affected. Orthokeratotic hyperkeratosis was a predominant histopathological feature in 17 dogs, occasionally accompanied by other lesions, including inclusion bodies (14/17), epidermal hyperplasia (9/17) and keratinocyte hydropic degeneration (6/17). Canine distemper virus antigen was expressed in at least one skin lesion in 10 dogs. Fourteen (14/17) hyperkeratotic foci were immunopositive while three (3/17) were immunonegative. Viral antigen expression was most common in the sweat glands (13/17), epidermis (11/17) and vascular endothelial cells or pericytes (8/17). Histological findings and antigen detection were similar among nasodigital and other regions. We emphasize the importance of clinicopathological recognition of these lesions for the initial suspicion of canine distemper, thereby facilitating early treatment.
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Databáze: MEDLINE
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