Non-melancholic depressive symptoms are associated with above average fat mass index in the Helsinki birth cohort study.

Autor: Eriksson MD; Primary Health Care Unit, Helsinki University Hospital (HUS), Helsinki, Finland. mia.eriksson@helsinki.fi.; Folkhälsan Research Center, Helsinki, Finland. mia.eriksson@helsinki.fi., Eriksson JG; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.; Department of Obstetrics and Gynecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.; Singapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR), Singapore, Singapore., Korhonen P; Department of General Practice, Turku University Hospital and University of Turku, Turku, Finland., Salonen MK; Folkhälsan Research Center, Helsinki, Finland.; Department of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland., Mikkola TM; Folkhälsan Research Center, Helsinki, Finland.; Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Kajantie E; Department of Public Health Solutions, Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway., Wasenius NS; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., von Bonsdorff M; Folkhälsan Research Center, Helsinki, Finland.; Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland., Kautiainen H; Folkhälsan Research Center, Helsinki, Finland.; Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland., Laine MK; Folkhälsan Research Center, Helsinki, Finland.; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Apr 28; Vol. 12 (1), pp. 6987. Date of Electronic Publication: 2022 Apr 28.
DOI: 10.1038/s41598-022-10592-3
Abstrakt: There is an existing link between two of the most common diseases, obesity and depression. These are both of great public health concern, but little is known about the relationships between the subtypes of these conditions. We hypothesized that non-melancholic depressive symptoms have a stronger relationship with both body composition (lean mass and fat mass) and dysfunctional glucose metabolism than melancholic depression. For this cross-sectional study 1510 participants from the Helsinki Birth Cohort Study had their body composition evaluated as lean mass and fat mass (Lean Mass Index [LMI, kg/m 2 ] + Fat Mass Index [FMI kg/m 2 ] = Body Mass Index). Participants were evaluated for depressive symptoms utilizing the Beck depression inventory, and had laboratory assessments including an oral glucose tolerance test. Higher than average FMI was associated with a higher percentage (mean [%], 95% CI) of participants scoring in the depressive range of the Beck depression inventory (20.2, 17.2-23.2) compared to those with low FMI (16.3, 13.8-18.9; p = 0.048) when adjusted for age, sex, education, and fasting plasma glucose concentration. Higher FMI was associated with a higher likelihood of having depressive symptoms (OR per 1-SD FMI = 1.37, 95% CI 1.13-1.65), whereas higher LMI was associated with a lower likelihood of having depressive symptoms (OR per 1-SD LMI = 0.76, 95% CI 0.64-0.91). Participants with an above average FMI more frequently (mean [%], 95% CI) had non-melancholic depressive symptoms (14.7, 11.8-17.7) as compared to those with low FMI (9.7, 7.6-11.9; p = 0.008) regardless of LMI levels. There was no difference between the body composition groups in the likelihood of having melancholic depressive symptoms. The non-melancholic group had higher (mean [kg/m 2 ], SD) FMI (9.6, 4.1) than either of the other groups (BDI < 10: 7.7, 3.1; melancholic: 7.9, 3.6; p < 0.001), and a higher (mean [mmol/l], SD) 2-h glucose concentration (7.21, 1.65) than the non-depressed group (6.71, 1.70; p = 0.005). As hypothesized, non-melancholic depressive symptoms are most closely related to high fat mass index and dysfunctional glucose metabolism.
(© 2022. The Author(s).)
Databáze: MEDLINE
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