Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.

Autor: Chari A; Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK.; Department of Neurosurgery, Great Ormond Street Hospital, London, UK., Seunarine KK; Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK.; Department of Neurosurgery, Great Ormond Street Hospital, London, UK., He X; Department of Bioengineering, Electrical & Systems Engineering, Physics & Astronomy, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.; Department of Psychology, School of Humanities and Social Sciences, University of Science and Technology of China, Hefei, Anhui, China., Tisdall MM; Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK.; Department of Neurosurgery, Great Ormond Street Hospital, London, UK., Clark CA; Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK., Bassett DS; Department of Bioengineering, Electrical & Systems Engineering, Physics & Astronomy, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.; Santa Fe Institute, Santa Fe, NM, USA., Scott RC; Developmental Neurosciences, Great Ormond Street Institute of Child Health, University College London, London, UK. rodney.scott@nemours.org.; Department of Paediatric Neurology, Great Ormond Street Hospital, London, UK. rodney.scott@nemours.org.; Department of Neurological Sciences, University of Vermont, Burlington, VT, USA. rodney.scott@nemours.org.; Department of Paediatric Neurology, Nemours Children's Hospital, Wilmington, DE, USA. rodney.scott@nemours.org., Rosch RE; Department of Bioengineering, Electrical & Systems Engineering, Physics & Astronomy, Neurology, and Psychiatry, University of Pennsylvania, Philadelphia, PA, USA.; Department of Paediatric Neurology, Great Ormond Street Hospital, London, UK.; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2022 Apr 28; Vol. 5 (1), pp. 394. Date of Electronic Publication: 2022 Apr 28.
DOI: 10.1038/s42003-022-03342-8
Abstrakt: Network control theory provides a framework by which neurophysiological dynamics of the brain can be modelled as a function of the structural connectome constructed from diffusion MRI. Average controllability describes the ability of a region to drive the brain to easy-to-reach neurophysiological states whilst modal controllability describes the ability of a region to drive the brain to difficult-to-reach states. In this study, we identify increases in mean average and modal controllability in children with drug-resistant epilepsy compared to healthy controls. Using simulations, we purport that these changes may be a result of increased thalamocortical connectivity. At the node level, we demonstrate decreased modal controllability in the thalamus and posterior cingulate regions. In those undergoing resective surgery, we also demonstrate increased modal controllability of the resected parcels, a finding specific to patients who were rendered seizure free following surgery. Changes in controllability are a manifestation of brain network dysfunction in epilepsy and may be a useful construct to understand the pathophysiology of this archetypical network disease. Understanding the mechanisms underlying these controllability changes may also facilitate the design of network-focussed interventions that seek to normalise network structure and function.
(© 2022. The Author(s).)
Databáze: MEDLINE
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