ERK1/2 is an ancestral organising signal in spiral cleavage.

Autor: Seudre O; School of Biological and Behavioural Sciences. Queen Mary University of London, Mile End Road, E1 4NS, London, UK., Carrillo-Baltodano AM; School of Biological and Behavioural Sciences. Queen Mary University of London, Mile End Road, E1 4NS, London, UK., Liang Y; School of Biological and Behavioural Sciences. Queen Mary University of London, Mile End Road, E1 4NS, London, UK., Martín-Durán JM; School of Biological and Behavioural Sciences. Queen Mary University of London, Mile End Road, E1 4NS, London, UK. chema.martin@qmul.ac.uk.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Apr 28; Vol. 13 (1), pp. 2286. Date of Electronic Publication: 2022 Apr 28.
DOI: 10.1038/s41467-022-30004-4
Abstrakt: Animal development is classified as conditional or autonomous based on whether cell fates are specified through inductive signals or maternal determinants, respectively. Yet how these two major developmental modes evolved remains unclear. During spiral cleavage-a stereotypic embryogenesis ancestral to 15 invertebrate groups, including molluscs and annelids-most lineages specify cell fates conditionally, while some define the primary axial fates autonomously. To identify the mechanisms driving this change, we study Owenia fusiformis, an early-branching, conditional annelid. In Owenia, ERK1/2-mediated FGF receptor signalling specifies the endomesodermal progenitor. This cell likely acts as an organiser, inducing mesodermal and posterodorsal fates in neighbouring cells and repressing anteriorising signals. The organising role of ERK1/2 in Owenia is shared with molluscs, but not with autonomous annelids. Together, these findings suggest that conditional specification of an ERK1/2 + embryonic organiser is ancestral in spiral cleavage and was repeatedly lost in annelid lineages with autonomous development.
(© 2022. The Author(s).)
Databáze: MEDLINE
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