Effects of aluminum chloride and coenzyme Q10 on the molecular structure of lipids and the morphology of the brain hippocampus cells.

Autor: Saeed A; Department of Physics, Faculty of Science, King Abdulaziz University Jeddah 21589 Saudi Arabia Abdusaeed79@hotmail.com Abdusaeed@tu.edu.ye +96 6563190832.; Department of Physics, Thamar University Thamar 87246 Yemen., Qusti SY; Biochemistry Department, Faculty of Science, King Abdulaziz University Jeddah Saudi Arabia., Almarwani RH; Biochemistry Department, Faculty of Science, King Abdulaziz University Jeddah Saudi Arabia., Jambi EJ; Biochemistry Department, Faculty of Science, King Abdulaziz University Jeddah Saudi Arabia.; King Fahd Medical Research Center Jeddah Saudi Arabia., Alshammari EM; Department of Chemistry, College of Sciences, University of Ha'il Ha'il 2440 Saudi Arabia., Gusty NF; Medical Laboratories Department, Faculty of Applied Medical Sciences, Umm Al-Qura University Mecca Saudi Arabia., Balgoon MJ; Biochemistry Department, Faculty of Science, King Abdulaziz University Jeddah Saudi Arabia.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2021 Sep 07; Vol. 11 (48), pp. 29925-29933. Date of Electronic Publication: 2021 Sep 07 (Print Publication: 2021).
DOI: 10.1039/d1ra03786b
Abstrakt: Aluminum chloride (AlCl 3 ) is a neurotoxic substance, while coenzyme Q10 (CoQ10) is considered a lipid antioxidant. Herein, their effects on the molecular structure of lipids and the morphology of the hippocampus brain tissue were investigated. Three groups of Wistar albino male rats were used in this study. For four weeks, one group was kept as a control group; the second group was given AlCl 3 ; the third group was given AlCl 3 /CoQ10. Fourier transform infrared (FTIR) and histopathological examinations were utilized to estimate alterations in the molecular structure of the lipids and the cell morphology, respectively. The FTIR spectra revealed considerable decreases in the CH contents and alterations in the molecular ratios of olefinic[double bond, length as m-dash]CH/ν as (CH 3 ), ν as (CH 2 )/ν as (CH 3 ), and ν as (CH 2 )/[ν as (CH 2 ) + ν s (CH 2 )] in the group given AlCl 3 . However, no significant changes were detected in those rats given AlCl 3 /CoQ10. Histopathology images uncovered shrinking and dark centers in the pyramidal cells of brain tissue hippocampal cells. The diameters of the pyramidal cells were estimated to be 4.81 ± 0.55 μm, 4.04 ± 0.71 μm, and 4.63 ± 0.71 μm for the control, AlCl 3 , and AlCl 3 /CoQ10 groups, respectively. The study showed that the AlCl 3 could cause a shrinking of around 16% in the hippocampus pyramidal cells; besides, CoQ10 is a powerful therapeutic antioxidant to help restore the hippocampal neurons to a regular state.
Competing Interests: The authors declare no conflict of interest.
(This journal is © The Royal Society of Chemistry.)
Databáze: MEDLINE
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