Comparative phytochemical analysis of five Egyptian strawberry cultivars ( Fragaria × ananassa Duch.) and antidiabetic potential of Festival and Red Merlin cultivars.

Autor:	El-Hawary SS; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University Cairo Egypt seham.elhawary@yahoo.com., Mohammed R; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University Beni-Suef Egypt rababmohammed@pharm.bsu.edu.eg abuh20050@yahoo.com., El-Din ME; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University Beni-Suef Egypt tonasalama28@gmail.com., Hassan HM; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University Beni-Suef Egypt rababmohammed@pharm.bsu.edu.eg abuh20050@yahoo.com.; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University Beni-Suef Egypt tonasalama28@gmail.com., Ali ZY; Department of Biochemistry, Egyptian Drug Authority (EDA), formerly National Organization for Drug Control and Research (NODCAR) Giza 12553 Egypt zeinabyousef65@ymail.com., Rateb ME; School of Computing, Engineering & Physical Sciences, University of the West of Scotland Paisley PA1 2BE Scotland UK mostafa.rateb@uws.ac.uk., Bellah El Naggar EM; Department of Pharmacognosy, Faculty of Pharmacy, Damanhur University Elbehira 22511 Egypt., Othman EM; Department of Biochemistry, Faculty of Pharmacy, Minia University 61519 Minia Egypt.; Department of Bioinformatics, Biocenter, University of Würzburg Am Hubland Würzburg Germany eman.sholkamy@uni-wuerzburg.de., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University 61111 New Minia Minia Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Minia University 61519 Minia Egypt usama.ramadan@mu.edu.eg.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2021 May 06; Vol. 11 (27), pp. 16755-16767. Date of Electronic Publication: 2021 May 06 (Print Publication: 2021).
DOI:	10.1039/d0ra10748d
Abstrakt:	This work aims to explore the differences in phytochemical composition and biological properties of five strawberry hybrids ( Fragaria × ananassa Duch.), and highlights the non-edible part (byproduct) as a source of self-remedy natural herb along with fruits. HPLC/DAD/HRESIMS technique was used in the dereplication of ten ethanolic extracts of five strawberry cultivars leaves and fruits (Festival, Red Merlin, Suzana, Tamar and Winter Dawn). Total phenolic and total flavonoid contents were established using Folin-Ciocalteu and aluminum chloride colorimetric assays, respectively. Ethanolic extracts of leaves and fruits from Festival and Red Merlin cultivars were selected to investigate their anti-hyperglycemic activity using streptozotocin-induced diabetic rats. Oxidative stress markers, lipid profile and kidney and liver function tests were assessed. The results revealed different chemical profiles of ten samples with the identification of 37 metabolites, represented mainly as flavonoids and phenolic acid derivatives. Phytochemical investigation resulted in the isolation of seven known phenolic compounds; quercetin, kaempferol, p -coumaric acid, p -tyrosol, methyl gallate, trans -tiliroside and eutigoside A. Suzana cultivar was the richest cultivar with flavonoids and total phenolics except for the total flavonoid content in leaves referred to Festival cultivar. Ethanolic extract of leaves, especially Festival cultivar was the most bioactive one. The results established the role of strawberry leaves along with fruits as an antioxidant and hypoglycemic natural remedy. Competing Interests: We declare that authors have no conflict of interest. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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