IL-27 Modulates the Cytokine Secretion in the T Cell-Osteoclast Crosstalk During HIV Infection.

Autor:	Li T; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, DC, United States., Hadigan C; Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States., Whitlock JM; Section on Membrane Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, United States., Qin J; Biostatistics Research Branch, Division of Clinical Research (DCR), National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, United States., Kumar J; Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine, Washington, DC, United States., Kumar P; Division of Infectious Diseases and Travel Medicine, Georgetown University School of Medicine, Washington, DC, United States., Catalfamo M; Department of Microbiology and Immunology, Georgetown University School of Medicine, Washington, DC, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2022 Apr 05; Vol. 13, pp. 818677. Date of Electronic Publication: 2022 Apr 05 (Print Publication: 2022).
DOI:	10.3389/fimmu.2022.818677
Abstrakt:	In People with HIV (PWH), chronic immune activation and systemic inflammation are associated with increased risk to develop comorbidities including bone loss. Numerous cells of the immune system, namely, T cells are involved in the regulation of the bone homeostasis and osteoclasts (OCs) activity. IL-27, a cytokine that belongs to the IL-12 family can regulate the secretion of pro- and anti-inflammatory cytokines by T cells, however its role in the setting of HIV is largely unknown. In the present study, we determined the impact of OCs in T cell secretion of cytokines and whether IL-27 can regulate this function. We found that the presence of OCs in the T cell cultures significantly enhanced secretion of IFNγ, TNFα, IL-17, RANKL, and IL-10 in both PWH and healthy controls. In PWH, IL-27 inhibited IL-17 secretion and downregulated surface expression of RANKL in CD4 T cells. All together these results suggest that in the context of HIV infection IL-27 may favor IFNγ and TNFα secretion at the sites of bone remodeling. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Li, Hadigan, Whitlock, Qin, Kumar, Kumar and Catalfamo.)
Databáze:	MEDLINE
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