Subcutaneous Panniculitis-Like T-Cell Lymphoma Revealed By Immunophenotyping of Necrosis.
| Autor: | Bellahsen-Harrar Y; Department of Pathology, CHU Henri Mondor, Creteil, France., Badrignans M; Department of Pathology, CHU Henri Mondor, Creteil, France.; Universite Paris-Est Creteil Val de Marne-Faculte de Medecine, Creteil, France; and., Cherif K; Department of Pathology, CHU Henri Mondor, Creteil, France., Papouin B; Department of Pathology, CHU Henri Mondor, Creteil, France.; Universite Paris-Est Creteil Val de Marne-Faculte de Medecine, Creteil, France; and., Ingen-Housz-Oro S; Department of Dermatology, CHU Henri Mondor, Creteil, France., Ortonne N; Department of Pathology, CHU Henri Mondor, Creteil, France.; Universite Paris-Est Creteil Val de Marne-Faculte de Medecine, Creteil, France; and. |
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| Jazyk: | angličtina |
| Zdroj: | The American Journal of dermatopathology [Am J Dermatopathol] 2022 Sep 01; Vol. 44 (9), pp. 675-676. Date of Electronic Publication: 2022 Apr 11. |
| DOI: | 10.1097/DAD.0000000000002203 |
| Abstrakt: | Abstract: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare but well-defined entity, often associated with autoimmune manifestations, generally with a good prognosis unless associated with hemophagocytic syndrome. Typically, the lymphoma cells rim the adipocytes and are characterized by a CD8 + cytotoxic phenotype. We report 2 cases of SPTCL where the first biopsies only showed subcutaneous fat necrosis without any lymphoma cell visible. The diagnoses were allowed by immunophenotypic markers which characterized necrotic neoplastic T cells and confirmed on further biopsies with a typical pattern of SPTCL. These observations should prompt dermatologists to perform as large biopsies as possible, and pathologists to perform immunophenotyping in all suspected cases even if only lobular necrosis is seen morphologically. Competing Interests: The authors declare no conflicts of interest. The authors of this article declare no conflict of interest. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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