Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms.

Autor: Margossian KO; Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, 01003, USA.; Rush Medical College, Rush University Medical Center, Chicago, IL, 60612, USA., Brown MU; Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, 01003, USA., Emrick T; Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, 01003, USA., Muthukumar M; Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, 01003, USA. muthu@polysci.umass.edu.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2022 Apr 26; Vol. 13 (1), pp. 2250. Date of Electronic Publication: 2022 Apr 26.
DOI: 10.1038/s41467-022-29851-y
Abstrakt: Traditionally, complex coacervation is regarded as a process whereby two oppositely charged polyelectrolytes self-assemble into spherical droplets. Here, we introduce the polyzwitterionic complex, "pZC", formed by the liquid-liquid phase separation of a polyzwitterion and a polyelectrolyte, and elucidate a mechanism by which such complexes can assemble using theory and experimental evidence. This system exhibits orthogonal phase behavior-it remains intact in acidic conditions, but disassembles as the pH increases, a process governed by the acid-base equilibria of the constituent chains. We relate the observed phase behavior to physiological conditions within the gastrointestinal tract with a simulation of the gastroduodenal junction, and demonstrate using video microscopy the viability of polyzwitterionic coacervates as technologies for the pH-triggered release of cargo. Such a system is envisaged to tackle imminent problems of drug transport via the oral route and serve as a packaging solution to increase uptake efficiency.
(© 2022. The Author(s).)
Databáze: MEDLINE
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