Assays of tongue force, timing, and dynamics in rat and mouse models.

Autor: Rudisch DM; Department of Surgery, Division of Otolaryngology - University of Wisconsin-Madison, Wisconsin School of Medicine and Public Health, United States; Department of Communication Sciences and Disorders - University of Wisconsin-Madison, United States. Electronic address: rudisch@wisc.edu., Krasko MN; Department of Surgery, Division of Otolaryngology - University of Wisconsin-Madison, Wisconsin School of Medicine and Public Health, United States; Department of Communication Sciences and Disorders - University of Wisconsin-Madison, United States., Nisbet AF; Department of Surgery, Division of Otolaryngology - University of Wisconsin-Madison, Wisconsin School of Medicine and Public Health, United States., Schaen-Heacock NE; Department of Surgery, Division of Otolaryngology - University of Wisconsin-Madison, Wisconsin School of Medicine and Public Health, United States; Department of Communication Sciences and Disorders - University of Wisconsin-Madison, United States., Ciucci MR; Department of Surgery, Division of Otolaryngology - University of Wisconsin-Madison, Wisconsin School of Medicine and Public Health, United States; Department of Communication Sciences and Disorders - University of Wisconsin-Madison, United States; Neuroscience Training Program - University of Wisconsin-Madison, United States.
Jazyk: angličtina
Zdroj: Brain research bulletin [Brain Res Bull] 2022 Jul; Vol. 185, pp. 49-55. Date of Electronic Publication: 2022 Apr 22.
DOI: 10.1016/j.brainresbull.2022.04.008
Abstrakt: Communication and swallowing are highly complex sensorimotor events that are tightly linked to respiration and vital to health and well-being. The tongue is a complex organ, often described as a muscular hydrostat, that is crucial for maintaining airway patency, preparing and safely transporting food/liquid, and rapidly changing position and shape for speech. As with any complex behavior, tongue function can be compromised with aging, diseases/conditions, trauma, or as a pharmacologic side effect. As such, modeling lingual function and dysfunction for basic and translational research is paramount; understanding how the nervous system controls tongue function for complex behavior is foundational to this work. Non-invasive access to tongue tissues and kinematics during awake behavior has been historically challenging, creating a critical need to measure tongue function in model systems. Germane to this field of study are the instruments and assays of licking/lapping and drinking, including tongue force and timing measures, many of which were designed or modified by Dr. Stephen C. Fowler. The focus of this paper is to review some of the important contributions of measuring tongue behaviors in awake rats and mice and how these have been modified by other researchers to advance translational science.
(Copyright © 2022 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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