Relationship between subjective report and objective assessment of neurocognitive functioning in persons with multiple sclerosis.

Autor:	Thomas GA; Department of Psychology, The Pennsylvania State University, State College, USA., Riegler KE; Department of Psychology, The Pennsylvania State University, State College, USA., Bradson ML; Department of Psychology, The Pennsylvania State University, State College, USA., O'Shea DU; Department of Psychiatry, Tufts University, School of Medicine, Boston, USA., Arnett PA; Department of Psychology, The Pennsylvania State University, State College, USA.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2023 Mar; Vol. 29 (3), pp. 266-273. Date of Electronic Publication: 2022 Apr 26.
DOI:	10.1017/S1355617722000212
Abstrakt:	Objective: Persons with multiple sclerosis (PwMS) are at increased risk for cognitive dysfunction. Considering the impact and potential ramifications of cognitive dysfunction, it is important that cognition is routinely assessed in PwMS. Thus, it is also important to identify a screener that is accurate and sensitive to MS-related cognitive difficulties, which can inform decisions for more resource-intensive neuropsychological testing. However, research focused on available self-report screeners has been mixed, such as with the Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ). This study aims to clarify the relationship between subjective and objective assessment of cognitive functioning in MS by examining domain-specific performance and intraindividual variability (IIV). Methods: 87 PwMS (F = 65, M = 22) completed a comprehensive neuropsychological battery which included self- and informant-report measures of neurocognitive functioning. Scores were examined in relation to mean performance on five domains of cognitive functioning and two measures of IIV. Results: The MSNQ-Self was inversely associated with executive function, verbal memory, and visual memory; it was not associated with IIV. The MSNQ-Informant was inversely associated with executive function and verbal memory, and positively associated with one measure of IIV. The MSNQ-Self showed a correlation of moderate effect size with depression ( r = .39) while the MSNQ-Informant did not. Conclusions: Results suggest that the MSNQ-Self and MSNQ-Informant show similar utility. Our findings also suggest that domains of executive function and memory may be most salient, thus more reflected in subjective reports of cognitive functioning. Future work should further examine the impact of mood disturbance with cognitive performance and IIV.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu