Immune dysfunction in the cerebellum of mice lacking the autism candidate gene Engrailed 2.

Autor: Pangrazzi L; CIMeC - Center for Mind/Brain Sciences, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, Trento, Italy. Electronic address: luca.pangrazzi-1@unitn.it., Genovesi S; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, via Sommarive 9, 38123 Trento, Italy., Balasco L; CIMeC - Center for Mind/Brain Sciences, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, Trento, Italy., Cerilli E; CIMeC - Center for Mind/Brain Sciences, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, Trento, Italy., Robol C; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, via Sommarive 9, 38123 Trento, Italy., Zunino G; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, via Sommarive 9, 38123 Trento, Italy., Piazza S; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, via Sommarive 9, 38123 Trento, Italy; Computational Biology, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy., Provenzano G; Department of Cellular, Computational, and Integrative Biology (CIBIO), University of Trento, via Sommarive 9, 38123 Trento, Italy., Bozzi Y; CIMeC - Center for Mind/Brain Sciences, University of Trento, Piazza della Manifattura 1, 38068 Rovereto, Trento, Italy; CNR Neuroscience Institute, via Moruzzi 1, 56124 Pisa, Italy. Electronic address: yuri.bozzi@unitn.it.
Jazyk: angličtina
Zdroj: Journal of neuroimmunology [J Neuroimmunol] 2022 Jun 15; Vol. 367, pp. 577870. Date of Electronic Publication: 2022 Apr 16.
DOI: 10.1016/j.jneuroim.2022.577870
Abstrakt: Immune system dysfunction has been described in autism spectrum disorder. Here we tested the hypothesis that cerebellar defects are accompanied by immune dysfunction in adult mice lacking the autism-candidate gene Engrailed 2 (En2). Gene ontology analyses revealed that biological processes related to immune function were over-represented in the cerebellar transcriptome of En2 -/- mice. Pro-inflammatory molecules and chemokines were reduced in the En2 -/- cerebellum compared to controls. Conversely, pro-inflammatory molecules were increased in the peripheral blood of mutant mice. Our results suggest a link between immune dysfunction and cerebellar defects detected in En2 -/- mice.
(Copyright © 2022 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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