Hunting out the autophagic problem in Huntington disease.
| Autor: | Pircs K; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, Lund, Sweden.; HCEMM-SU, Neurobiology and Neurodegenerative Diseases Research Group, Budapest, Hungary.; Institute of Translational Medicine, Semmelweis University, Budapest, Hungary., Barker RA; Wellcome-MRC Cambridge Stem Cell Institute & John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Forvie Site, Cambridge, UK., Jakobsson J; Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, BMC A11, Lund University, Lund, Sweden. |
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| Jazyk: | angličtina |
| Zdroj: | Autophagy [Autophagy] 2022 Dec; Vol. 18 (12), pp. 3031-3032. Date of Electronic Publication: 2022 May 03. |
| DOI: | 10.1080/15548627.2022.2069438 |
| Abstrakt: | Huntington disease is an inherited, progressive, incurable neurodegenerative disorder that primarily affects cells in the brain. Although the genetic basis for this condition has been known for nearly 30 years, how this causes disease is still unresolved. Of late there has been increasing evidence suggesting that dysfunction in macroautophagic/autophagic pathways may contribute to cellular dysfunction and death. In our recent work we highlight more precisely how and where this problem might arise in this pathway using directly reprogrammed neurons. |
| Databáze: | MEDLINE |
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