Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study.

Autor:	Eckhardt CM; Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA., Balte PP; Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA., Barr RG; Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA., Bertoni AG; Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Bhatt SP; Division of Pulmonary, University of Alabama at Birmingham, Allergy and Critical Care Medicine, Birmingham, AL, USA., Cuttica M; Department of Medicine, Northwestern University, Chicago, IL, USA., Cassano PA; Division of Nutritional Sciences, Cornell University, College of Human Ecology, Cornell, NY, USA., Chaves P; Department of Health and Society, Florida International University, Miami, FL, USA., Couper D; Department of Biostatistics, University of North Carolina, Chapel Hill, NC, USA., Jacobs DR; Division of Epidemiology and Community Health, University of Minnesota, School of Public Health, Minneapolis, MN, USA., Kalhan R; Department of Medicine, Northwestern University, Chicago, IL, USA., Kronmal R; Department of Statistics, University of Washington, School of Public Health, Seattle, WA, USA., Lange L; Department of Medicine, University of Colorado, Denver, CO, USA., Loehr L; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., London SJ; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA., O'Connor GT; Department of Medicine, Boston University, Boston, MA, USA., Rosamond W; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA., Sanders J; Division of Pulmonary Medicine, Brigham and Women's Hospital, Boston, MA, USA., Schwartz JE; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA., Shah A; Division of Cardiovascular Medicine, Brigham and Women's Hospital, Boston, MA, USA., Shah SJ; Department of Medicine, Northwestern University, Chicago, IL, USA., Smith L; Department of Medicine, Northwestern University, Chicago, IL, USA., White W; Undergraduate Training and Education Center, Tougaloo College, Jackson Heart Study, Jackson, MS, USA., Yende S; Department of Critical Care Medicine, Veterans Affairs Pittsburgh Healthcare System and University of Pittsburgh, Pittsburgh, PA, USA., Oelsner EC; Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, Presbyterian Hospital 9th Floor, Suite 105, New York, NY 10032, USA.
Jazyk:	angličtina
Zdroj:	European heart journal [Eur Heart J] 2022 Jun 14; Vol. 43 (23), pp. 2196-2208.
DOI:	10.1093/eurheartj/ehac205
Abstrakt:	Aims: The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF). Methods and Results: Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Participants with self-reported baseline cardiovascular disease were excluded. Spirometry was used to define obstructive [forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.70] or restrictive (FEV1/FVC ≥0.70, FVC <80%) lung physiology. The incident HF was defined as hospitalization or death caused by HF. In a sub-set, HF events were sub-classified as HF with reduced ejection fraction (HFrEF; EF <50%) or preserved EF (HFpEF; EF ≥50%). The Fine-Gray proportional sub-distribution hazards models were adjusted for sociodemographic factors, smoking, and cardiovascular risk factors. In models of incident HF sub-types, HFrEF, HFpEF, and non-HF mortality were treated as competing risks. Among 31 677 adults, there were 3344 incident HF events over a median follow-up of 21.0 years. Of 2066 classifiable HF events, 1030 were classified as HFrEF and 1036 as HFpEF. Obstructive [adjusted hazard ratio (HR) 1.17, 95% confidence interval (CI) 1.07-1.27] and restrictive physiology (adjusted HR 1.43, 95% CI 1.27-1.62) were associated with incident HF. Obstructive and restrictive ventilatory defects were associated with HFpEF but not HFrEF. The magnitude of the association between restrictive physiology and HFpEF was similar to associations with hypertension, diabetes, and smoking. Conclusion: Lung function impairment was associated with increased risk of incident HF, and particularly incident HFpEF, independent of and to a similar extent as major known cardiovascular risk factors. (© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Cardiology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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