Retinoic acid-induced protein 14 controls dendritic spine dynamics associated with depressive-like behaviors.

Autor:	Kim SJ; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Woo Y; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Kim HJ; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Goo BS; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Nhung TTM; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Lee SA; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Suh BK; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Mun DJ; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Kim JH; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea., Park SK; Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2022 Apr 25; Vol. 11. Date of Electronic Publication: 2022 Apr 25.
DOI:	10.7554/eLife.77755
Abstrakt:	Dendritic spines are the central postsynaptic machinery that determines synaptic function. The F-actin within dendritic spines regulates their dynamic formation and elimination. Rai14 is an F-actin-regulating protein with a membrane-shaping function. Here, we identified the roles of Rai14 for the regulation of dendritic spine dynamics associated with stress-induced depressive-like behaviors. Rai14-deficient neurons exhibit reduced dendritic spine density in the Rai14 +/- mouse brain, resulting in impaired functional synaptic activity. Rai14 was protected from degradation by complex formation with Tara, and accumulated in the dendritic spine neck, thereby enhancing spine maintenance. Concurrently, Rai14 deficiency in mice altered gene expression profile relevant to depressive conditions and increased depressive-like behaviors. Moreover, Rai14 expression was reduced in the prefrontal cortex of the mouse stress model, which was blocked by antidepressant treatment. Thus, we propose that Rai14-dependent regulation of dendritic spines may underlie the plastic changes of neuronal connections relevant to depressive-like behaviors. Competing Interests: SK, YW, HK, BG, TN, SL, BS, DM, JK, SP No competing interests declared (© 2022, Kim et al.)
Databáze:	MEDLINE
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