Oral amoxicillin/clavulanate for the prevention of bacteremia following dental extractions.

Autor: Diniz Freitas M; Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain., Álvarez Fernández M; Department of Microbiology, Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur) SERGAS-Universidade de Vigo, Complexo Hospitalario Universitario de Vigo (CHUVI), Sergas, Vigo, Spain., Vasallo Vidal FJ; Department of Microbiology, Microbiology and Infectology Research Group, Galicia Sur Health Research Institute (IIS Galicia Sur) SERGAS-Universidade de Vigo, Complexo Hospitalario Universitario de Vigo (CHUVI), Sergas, Vigo, Spain., Limeres Posse J; Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain., Diz Dios P; Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain., Fernández Feijoo J; Medical-Surgical Dentistry Research Group (OMEQUI), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela (USC), Santiago de Compostela, Spain.
Jazyk: angličtina
Zdroj: Oral diseases [Oral Dis] 2023 Jul; Vol. 29 (5), pp. 2272-2276. Date of Electronic Publication: 2022 May 13.
DOI: 10.1111/odi.14221
Abstrakt: This study aimed to evaluate the effectiveness of oral amoxicillin/clavulanate (AMX-CL) for the prevention of bacteremia following dental extractions. The study group (AMX-CLG) comprised 40 adults requiring dental extractions under general anesthesia who were administered a prophylactic regimen of 1875/125 mg of AMX-CL orally 1-2 h prior to the surgery. Venous blood samples were collected from each patient at baseline and at 30 s and 15 min after dental extractions. Samples were inoculated into BACTEC Plus culture bottles and processed in the BACTEC 9240. Conventional microbiological techniques were used for subcultures and further identification of the isolated bacteria. The results for the AMX-CLG were compared with those of a control group (CG; no prophylaxis) and an amoxicillin group (AMXG; 2 g of amoxicillin orally), consisting of randomly selected patients from among those participating in two clinical trials that we have previously published. The prevalence of bacteremia in the CG, AMXG, and AMX-CLG was 97%, 50%, and 15%, respectively, at 30 s after completing the extractions, and 67%, 10%, and 4% at 15 min, respectively, after the last extraction. The prevalence of bacteremia in the AMXG and the AMX-CLG at 30 s and at 15 min after completing the extractions was significantly lower than that in the CG (p < 0.001 and p < 0.001, respectively; Fisher's exact test). The prevalence of bacteremia in the AMX-CLG at 30 s after completing the extractions was significantly lower than that in the AMXG (p < 0.001; Fisher's exact test). Based in the results of this preliminary study, oral AMX-CL could be an excellent option for preventing bacteremia secondary to dental procedures in patients at risk.
(© 2022 The Authors. Oral Diseases published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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