| Autor: |
Gonzalez J; Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.; Department of Pharmacy, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA., Upadhyaya VD; Department of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA., Manna ZT; Rowan University School of Osteopathic Medicine, Glassboro, NJ, USA., Sharma AR; Xavier University School of Medicine, Oranjestad, Aruba., Christopher J; Department of Psychiatry, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA., Douedi S; Department of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA., Sen S; Department of Internal Medicine, Hackensack Meridian Health Jersey Shore University Medical Center, Neptune, NJ, USA. |
| Abstrakt: |
Benzodiazepines are commonly used medications which are clinically useful towards the treatment of alcohol withdrawal, seizures, anxiety disorders, among other indications. Benzodiazepine use is also known to cause the rare phenomenon of paradoxical excitation whose mechanism has many postulated theories. We report this rare presentation of paradoxical excitation with the use of lorazepam in a 50-year-old male being treated for alcohol withdrawal. We also review the underlying pathophysiology, pharmacology, and current literature as it relates to this excitation. An inability to recognize this adverse effect and to appropriately withhold the agent may adversely affect a patient's course of treatment in the inpatient setting. |
