Alcohol use and cognitive aging in middle-aged men: The Vietnam Era Twin Study of Aging.

Autor:	Garduno AC; Division of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, CA, USA.; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA., Laughlin GA; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA., Bergstrom J; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA., Tu XM; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA., Cummins KM; Department of Public Health, California State University, Fullerton, CA, USA., Franz CE; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA., Elman JA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA., Lyons MJ; Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA., Reynolds CA; Department of Psychology, University of California Riverside, Riverside, CA, USA., Neale MC; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Gillespie NA; Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Xian H; Department of Statistics, St Louis University, St Louis, MO, USA.; Research Service, VA St Louis Healthcare System, St Louis, MO, USA., McKenzie RE; Department of Psychology, Boston University, Boston, MA, USA.; Department of Applied Human Development and Community Studies, Merrimack College, North Andover, MA, USA., Toomey R; Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA., Kremen WS; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA., Panizzon MS; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.; Center for Behavior Genetics of Aging, University of California San Diego, San Diego, CA, USA., McEvoy LK; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, San Diego, CA, USA.
Jazyk:	angličtina
Zdroj:	Journal of the International Neuropsychological Society : JINS [J Int Neuropsychol Soc] 2023 Mar; Vol. 29 (3), pp. 235-245. Date of Electronic Publication: 2022 Apr 25.
DOI:	10.1017/S1355617722000169
Abstrakt:	Objective: To determine associations of alcohol use with cognitive aging among middle-aged men. Method: 1,608 male twins (mean 57 years at baseline) participated in up to three visits over 12 years, from 2003-2007 to 2016-2019. Participants were classified into six groups based on current and past self-reported alcohol use: lifetime abstainers, former drinkers, very light (1-4 drinks in past 14 days), light (5-14 drinks), moderate (15-28 drinks), and at-risk drinkers (>28 drinks in past 14 days). Linear mixed-effects regressions modeled cognitive trajectories by alcohol group, with time-based models evaluating rate of decline as a function of baseline alcohol use, and age-based models evaluating age-related differences in performance by current alcohol use. Analyses used standardized cognitive domain factor scores and adjusted for sociodemographic and health-related factors. Results: Performance decreased over time in all domains. Relative to very light drinkers, former drinkers showed worse verbal fluency performance, by -0.21 SD (95% CI -0.35, -0.07), and at-risk drinkers showed faster working memory decline, by 0.14 SD (95% CI 0.02, -0.20) per decade. There was no evidence of protective associations of light/moderate drinking on rate of decline. In age-based models, light drinkers displayed better memory performance at advanced ages than very light drinkers (+0.14 SD ; 95% CI 0.02, 0.20 per 10-years older age); likely attributable to residual confounding or reverse association. Conclusions: Alcohol consumption showed minimal associations with cognitive aging among middle-aged men. Stronger associations of alcohol with cognitive aging may become apparent at older ages, when cognitive abilities decline more rapidly.
Databáze:	MEDLINE
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