Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers.

Autor: Varghese EJ; Department of Conservative Dentistry and Endodontics, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, SRM Nagar Kattankulathur, Kanchipuram, Chennai 603203, Tamil Nadu, India., Sihivahanan D; Department of Conservative Dentistry and Endodontics, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, SRM Nagar Kattankulathur, Kanchipuram, Chennai 603203, Tamil Nadu, India., Venkatesh KV; Department of Conservative Dentistry and Endodontics, SRM Kattankulathur Dental College and Hospital, SRM Institute of Science and Technology, SRM Nagar Kattankulathur, Kanchipuram, Chennai 603203, Tamil Nadu, India.
Jazyk: angličtina
Zdroj: International journal of biomaterials [Int J Biomater] 2022 Apr 12; Vol. 2022, pp. 3912290. Date of Electronic Publication: 2022 Apr 12 (Print Publication: 2022).
DOI: 10.1155/2022/3912290
Abstrakt: Objectives: To assess the antibacterial efficacy of experimental dental composite resin with cerium oxide nanoparticles as fillers.
Methods: The cerium oxide nanoparticles were prepared by the coprecipitation procedure. Synthesized 3wt% CeO 2 nanoparticles were added to the composite resin as antibacterial filler. Experimental composite resin was manually prepared by adding ingredients. The resin matrix consisted of two mixed monomers, bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate, diketone as the photo initiator, and N, N-dimethylaminoethyl methacrylate as a coinitiator. The antibacterial efficacy against Streptococcus mutans , Streptococcus mitis , Streptococcus aureus , and Lactobacillus spp. bacterial strains was tested using the microdilution method keeping commercially available 3M Filtek Z250 restorative composite as control.
Results: The experimental dental composite demonstrated 99.503% efficacy against Streptococcus mutans , 99.441% efficacy against Streptococcus mitis , 99.416% efficacy against Streptococcus aureus , and 99.233% efficacy against Lactobacillus spp.
Conclusion: Integrating cerium oxide nanoparticles as fillers into dental composite resin can be promising in terms of antibacterial activity, provided furthermore study has to be conducted to examine other properties. Clinical Significance . Previous studies attempted adding CeO 2 nanoparticles into acrylic resins that showed improvement in mechanical properties, but literature is nil on the dental composite resin and cerium oxide nanoparticles. This study demonstrates the development of an experimental antibacterial dental composite resin that can resolve most of the problems related to secondary caries around dental composite restorations.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2022 Eldho Jijy Varghese et al.)
Databáze: MEDLINE
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