Clinicopathological Significance of PTEN Expression and Its Prognostic Effect in Colorectal Adenocarcinoma Patients.

Autor: Mirzapour Abbas Abadi Z; Department of Molecular Medicine, Faculty of Medical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran., Samiee Rad F; Department of Pathology, Faculty of Medical School, Qazvin University of Medical Sciences, Qazvin, Iran., Hamedi Asl D; Department of Pathology and Molecular Medicine, Mehr Laboratory, Hashtgerd, Iran., Rahmani B; Department of Molecular Medicine, Faculty of Medical Sciences, Qazvin University of Medical Sciences, Qazvin, Iran., Soleimani Dodaran M; Department of Pathology and Molecular Medicine, Mehr Laboratory, Hashtgerd, Iran., Peimani A; Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Jazyk: angličtina
Zdroj: Iranian journal of pathology [Iran J Pathol] 2022 Spring; Vol. 17 (2), pp. 150-158. Date of Electronic Publication: 2022 Mar 08.
DOI: 10.30699/IJP.2021.531779.2653
Abstrakt: Background & Objective: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene located at chromosome 10. PTEN is a regulator of the PI3K/AKT signaling pathway that inhibits cell proliferation and promotes apoptosis. PTEN loss of function occurs in a spectrum of cancers, including colorectal adenocarcinoma. This study aimed to investigate the probable correlation of negative PTEN expression with clinicopathological features and colorectal adenocarcinoma (CRC) patients' survival.
Methods: In this cross-sectional study using Immunohistochemistry stainingPTEN expression status on 151 CRC tissues was evaluated. Then the results of IHC staining was compared to those of clinicopathological features. The relationship between PTEN and KRAS mutation status was also investigated.
Results: Of 151 CRC samples, 89 (58.9%) were negative for PTEN expression. Loss of PTEN expression was associated with KRAS mutation ( P <0.0001), lymph node metastasis ( P =0.002), and advanced tumor stage ( P =0.016), whereas no significant association was found with other clinicopathological features. Multivariate analysis indicated that tumor site and KRAS mutation were independent prognostic CRC patients ( P <0.05). The Kaplan-Meier analysis indicated a correlation between loss of PTEN expression and overall survival of patients with colorectal adenocarcinoma ( P = 0.01).
Conclusion: The current study suggests that decreasing PTEN expression or its negative expression may be associated with a higher stage and poor prognosis. Combined analysis of mutated KRAS and PTEN expression could be a good predictor of disease prognosis as well as its clinical outcomes.
Competing Interests: The authors declared no conflict of interest.
Databáze: MEDLINE
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