Role of Apoptosis in HIV Pathogenesis.

Autor: Jabea Ekabe C; Grace Community Health and Development Association, P. O. Box 15, Kumba, Southwest Region, Cameroon.; Mbonge District Hospital, Mbonge, South West Region, Cameroon.; Faculty of Health Sciences, University of Buea, Buea, Cameroon., Asaba Clinton N; Grace Community Health and Development Association, P. O. Box 15, Kumba, Southwest Region, Cameroon.; Faculty of Health Sciences, University of Buea, Buea, Cameroon.; Health and Empowerment Foundation, Kumba, Cameroon., Agyei EK; Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Kehbila J; Grace Community Health and Development Association, P. O. Box 15, Kumba, Southwest Region, Cameroon.; Faculty of Health Sciences, University of Buea, Buea, Cameroon.; Wum District Hospital, Wum, Northwest Region, Cameroon.
Jazyk: angličtina
Zdroj: Advances in virology [Adv Virol] 2022 Apr 14; Vol. 2022, pp. 8148119. Date of Electronic Publication: 2022 Apr 14 (Print Publication: 2022).
DOI: 10.1155/2022/8148119
Abstrakt: The apoptotic pathway is an important cell death pathway that contributes to the maintenance of homeostasis in living systems. However, variations in apoptosis have been linked to many diseases such as cancers and chronic infections. The HIV infection has contributed to increase mortality and morbidity worldwide, predominantly through the induction of gradual depletion of CD4+ T cells. The induction and mediation of both the intrinsic and extrinsic apoptotic pathways are crucial in HIV pathogenesis and intracellular survival. Consequently, a deep molecular understanding of how apoptosis is induced and modulated in HIV-mediated CD4+ T cell depletion is paramount, as this can lead to new portals of therapeutic intervention and control.
Competing Interests: The authors declare that they have no conflicts of interests.
(Copyright © 2022 Cyril Jabea Ekabe et al.)
Databáze: MEDLINE
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