Neurophysiological functions and pharmacological tools of acidic and non-acidic Ca 2+ stores.

Autor: Martucci LL; Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, UK.. Electronic address: lora.martucci@new.ox.ac.uk., Cancela JM; Neuroscience Paris-Saclay Institute (Neuro-PSI), UMR 9197, CNRS- University Paris-Sud, Campus CEA, 151 Rte de la Rotonde, 91400 Saclay, France.. Electronic address: jose-manuel.cancela@universite-paris-saclay.fr.
Jazyk: angličtina
Zdroj: Cell calcium [Cell Calcium] 2022 Jun; Vol. 104, pp. 102582. Date of Electronic Publication: 2022 Apr 10.
DOI: 10.1016/j.ceca.2022.102582
Abstrakt: Ca 2+ signalling is of prime importance in controlling numerous cell functions in the brain. Endolysosomes are acidic organelles currently emerging as important Ca 2+ stores in astrocytes, microglia, endothelial cells, and neurons. In neurons, these acidic Ca 2+ stores are found in axons, soma, dendrites, and axon endings and could provide local sources of Ca 2+ to control synaptic transmission, neuronal plasticity, and autophagy to name a few. This review will address how acidic Ca 2+ stores are recruited in response to cell stimulation. We will focus on the role of the endolysosomal two-pore channels (TPCs) and their physiological agonist nicotinic acid adenine dinucleotide phosphate (NAADP) and how they interact with cyclic ADP-ribose and ryanodine receptors from the endoplasmic reticulum. Finally, this review will describe new pharmacological tools and animal mutant models now available to explore acidic Ca 2+ stores as key elements in brain function and dysfunction.
(Copyright © 2022. Published by Elsevier Ltd.)
Databáze: MEDLINE
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