Impact of CDC warning on co-prescribing of opioids and benzodiazepines in older allogeneic hematopoietic cell transplant recipients.

Autor: Bhargava D; St Paul Academy and Summit School, St. Paul, Min, USA., Drilling C; St Paul Academy and Summit School, St. Paul, Min, USA., DeFor TE; Biostatistics, CTSI, University of Minnesota, Minneapolis, MN, USA., Brunstein CG; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA., Thyagarajan B; Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., El Jurdi N; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA., Holtan SG; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA., Rashidi A; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA., Warlick E; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA., Ramesh V; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, USA., Rogosheske J; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA., Arora M; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA. arora005@umn.edu., Bhatia S; Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, AL, USA., Weisdorf DJ; Division of Hematology, Oncology and Transplant, University of Minnesota, Minneapolis, MN, USA.
Jazyk: angličtina
Zdroj: Bone marrow transplantation [Bone Marrow Transplant] 2022 Jul; Vol. 57 (7), pp. 1079-1085. Date of Electronic Publication: 2022 Apr 23.
DOI: 10.1038/s41409-022-01654-1
Abstrakt: The use of opioids and/or benzodiazepines in older adults (65 y+) who received an allogeneic hematopoietic cell transplant (HCT) is not known. In March 2016, the CDC released its strongest guidelines against prescription of opioids and co-prescription of opioids + benzodiazepines. We evaluated the use of opioids and/or benzodiazepines in older (65 y + , n = 114) vs. younger (40-64 y, n = 240) allogeneic-HCT recipients before and after the CDC guidelines. The proportion of patients with >10-days of use of opioids and/or benzodiazepines peri-HCT (day-14 to +28) was compared. Opioids: the older (65 + y) group had similar odds of receiving opioids as the younger group (40-64 y) [O.R. 0.7 (95%CI:0.4-1.2)]. Those transplanted after the CDC guideline had 0.4 (95%CI:0.2-0.7) times the odds of receiving opioids. Benzodiazepines: The older (65 + y) group was 0.6 times (95%CI:0.3-0.9) as likely to receive benzodiazepines. There was no significant change in benzodiazepines use after the CDC guideline. Opioids + Benzodiazepines: The older group (65 + y) was 0.5 (95%CI:0.3-0.9) times as likely to receive both opioids+benzodiazepines. There was no significant change in opioids+benzodiazepines use after the CDC guideline. Though we observed a significant decrease in use of opioids after the CDC guideline, the use of benzodiazepines and combined opioids+benzodiazepines remained constant. Older recipients (65 + y) received less opioids, benzodiazepines, and combined opioids+benzodiazepines.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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