Anti-obesity effects of the n-butanol fraction of the methanolic leaf extract of Artemisia campestris from Tunisian pharmacopeia in male Wistar rats.

Autor:	Belgacem A; Department of Biology, Research Unit of Physiology of Regulatory Systems and Adaptations, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia., Senejoux F; University of Clermont Auvergne, University of Auvergne, Clermont-Ferrand, France.; INRA, UMR 1019, Clermont-Ferrand, France., Felgines C; University of Clermont Auvergne, University of Auvergne, Clermont-Ferrand, France.; INRA, UMR 1019, Clermont-Ferrand, France., Fraisse D; University of Clermont Auvergne, University of Auvergne, Clermont-Ferrand, France.; INRA, UMR 1019, Clermont-Ferrand, France., Bitri L; Department of Biology, Research Unit of Physiology of Regulatory Systems and Adaptations, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia., Khemiri I; Department of Biology, Research Unit of Physiology of Regulatory Systems and Adaptations, Faculty of Sciences of Tunis, University of Tunis El Manar, Tunis, Tunisia.
Jazyk:	angličtina
Zdroj:	Journal of complementary & integrative medicine [J Complement Integr Med] 2022 Apr 25; Vol. 19 (2), pp. 365-373. Date of Electronic Publication: 2022 Apr 25 (Print Publication: 2022).
DOI:	10.1515/jcim-2022-0018
Abstrakt:	Objectives: This study aimed to investigate the effect of the n-butanol fraction of the methanol leaf extract of Artemisia campestris (BFAC), growing wild in the arid zone of Tunisia, on induced obesity in male Wistar rats. Methods: The total phenolic content and antioxidant capacity of the BFAC were estimated. The main phenolic composition of the BFAC was determined using the high-performance chromatography system coupled with a diode array detector technics. Five groups of rats received either a standard diet (SD group), a high-fat diet (HFD group), or an HFD supplemented with oral administration of BFAC for eight weeks. Results: The BFAC showed higher phenolic content and antioxidant potential than the total leaf methanol extract. Chlorogenic acid, rutin, and dicaffeoylquinic acids were identified in the BFAC. HFD increased body and relative liver weights, as well as serum and hepatic levels of triglycerides and total cholesterol, compared to SD. HFD generated significant oxidative stress in the liver by increasing lipid peroxidation and reducing glutathione-S-transferase, catalase, and glutathione peroxidase activities, compared to SD. These HFD-altered parameters were restored to normal values by oral treatment with the BFAC. Conclusions: These findings give first evidence about the antiobesity efficacy of A. campestris . Such a study would enhance existing information and promote the use of this species. (© 2022 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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