Cytotoxic benzylidene hydrazides of terephthalic acid and related compounds.

Autor:	Hossain M; School of Sciences, Indiana University Kokomo, Kokomo, USA;, Email: mohoss@iu.edu., Hall SC; School of Sciences, Indiana University Kokomo, Kokomo, USA., Wiggington PJ; School of Sciences, Indiana University Kokomo, Kokomo, USA., Roth SM; School of Sciences, Indiana University Kokomo, Kokomo, USA., Das S; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada., Das U; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada., Roayapalley PK; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada., Dimmock JR; Drug Discovery and Development Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada.
Jazyk:	angličtina
Zdroj:	Die Pharmazie [Pharmazie] 2022 Apr 10; Vol. 77 (3), pp. 90-94.
DOI:	10.1691/ph.2022.11072
Abstrakt:	The present investigation involved the synthesis of a number of novel benzylidene hydrazides as candidate cytotoxic agents. The preparation of these compounds from terephthalic acid and isophthalic acid proceeded satisfactorily. However, the reaction of phthalic acid hydrazide with various aryl aldehydes was unsuccessful in general. Some of the unexpected products were identified. The shapes and also the distances between the centers of the aryl rings designated B and C of three representative compounds 1b , 2b and 3b were determined. The compounds designated 1a-e , 2a-e and 3b were screened against human HCT116 and HT29 colon cancer cells as well as human CRL1790 non-malignant colon cells which revealed the tumor-selective toxicity displayed by these compounds.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu