| Autor: |
Adamoski D; Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas 13083-970, Brazil., Baura VA; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba 81530-000, Brazil., Rodrigues AC; Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Brazil., Royer CA; Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Brazil., Aoki MN; Carlos Chagas Institute, FioCruz, Curitiba 81310-020, Brazil., Tschá MK; Molecular Biology Institute of Paraná, Curitiba 81310-020, Brazil., Bonatto AC; Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Brazil., Wassem R; Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Brazil., Nogueira MB; Virology Laboratory, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba 80060-900, Brazil., Raboni SM; Virology Laboratory, Complexo Hospital de Clínicas, Universidade Federal do Paraná, Curitiba 80060-900, Brazil., Almeida BMM; HiLab Laboratories, Curitiba 81270-185, Brazil., Trindade EDS; Department of Cellular Biology, Federal University of Paraná, Curitiba 81530-000, Brazil., Gradia DF; Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Brazil., Souza EM; Department of Biochemistry and Molecular Biology, Federal University of Paraná, Curitiba 81530-000, Brazil., Carvalho de Oliveira J; Department of Genetics, Universidade Federal do Paraná, Curitiba 81531-980, Brazil. |
| Abstrakt: |
Screening efforts and genomic surveillance are essential tools to evaluate the course of the COVID-19 pandemic and assist the public healthcare system in dealing with an increasing number of infections. For the analysis of COVID-19 cases scenarios in Curitiba, Paraná, Brazil, we performed a diagnosis of positive cases, coupled with genotyping, for symptomatic and asymptomatic members of the Federal University of Paraná. We achieved over 1000 samples using RT-qPCR for diagnosis. The posterior genotyping allowed us to observe differences in the spread of strains in Curitiba, Brazil. The Delta variant was not associated with an infection wave, whereas the rapid Omicron variant spread became dominant in less than one month. We also evaluated the general vaccination coverage in the state, observing a striking reduction in lethality correlated to the vaccinated fraction of the population; although lower lethality rates were not much affected by the Omicron variant wave, the same effect was not translated in the number of infections. In summary, our results provide a general overview of the pandemic's course in Paraná State and how there was reduction in lethality after a combination of multiple infection waves and a large-scale vaccination program. |
