Inactivation Rates for Airborne Human Coronavirus by Low Doses of 222 nm Far-UVC Radiation.

Autor: Welch D; Center for Radiological Research, Columbia University Irving Medical Center, New York, NY 10032, USA., Buonanno M; Center for Radiological Research, Columbia University Irving Medical Center, New York, NY 10032, USA., Buchan AG; School of Engineering and Materials Science, Queen Mary University of London, London E1 4NS, UK., Yang L; School of Water, Energy and Environment (SWEE), Cranfield University, Bedford MK43 0AL, UK., Atkinson KD; Faculty of Energy Systems and Nuclear Science, Ontario Tech University, Oshawa, ON L1G 0C5, Canada., Shuryak I; Center for Radiological Research, Columbia University Irving Medical Center, New York, NY 10032, USA., Brenner DJ; Center for Radiological Research, Columbia University Irving Medical Center, New York, NY 10032, USA.
Jazyk: angličtina
Zdroj: Viruses [Viruses] 2022 Mar 25; Vol. 14 (4). Date of Electronic Publication: 2022 Mar 25.
DOI: 10.3390/v14040684
Abstrakt: Recent research using UV radiation with wavelengths in the 200-235 nm range, often referred to as far-UVC, suggests that the minimal health hazard associated with these wavelengths will allow direct use of far-UVC radiation within occupied indoor spaces to provide continuous disinfection. Earlier experimental studies estimated the susceptibility of airborne human coronavirus OC43 exposed to 222-nm radiation based on fitting an exponential dose-response curve to the data. The current study extends the results to a wider range of doses of 222 nm far-UVC radiation and uses a computational model coupling radiation transport and computational fluid dynamics to improve dosimetry estimates. The new results suggest that the inactivation of human coronavirus OC43 within our exposure system is better described using a bi-exponential dose-response relation, and the estimated susceptibility constant at low doses-the relevant parameter for realistic low dose rate exposures-was 12.4 ± 0.4 cm 2 /mJ, which described the behavior of 99.7% ± 0.05% of the virus population. This new estimate is more than double the earlier susceptibility constant estimates that were based on a single-exponential dose response. These new results offer further evidence as to the efficacy of far-UVC to inactivate airborne pathogens.
Databáze: MEDLINE
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